Changes in Clinic-Level STI Burden After Doxycycline Post-Exposure Prophylaxis Implementation in an Urban Sexual Health Clinic.

In an urban sexual health clinic, a substantial portion of the clinic population initiated doxycycline postexposure prophylaxis (doxyPEP) for bacterial STIs in the first 12 months, and implementation of doxyPEP was associated with a subsequent decrease in clinic-level chlamydia and syphilis positivity, but no change in overall gonorrhea positivity.