Alcohol (Fayetteville, N.Y.) · 2026
Effects of acute alcohol on pain-related activity of the anterior and posterior insular cortices.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Cushnie Adriana K, Sevel Landrew S, Bush Nicholas J, Nixon Sara Jo, Robinson Michael E, Boissoneault Jeff
Аннотация
BACKGROUND: Self-medicating pain with alcohol is common. Chronic heavy alcohol use is associated with increased risk for chronic pain and alcohol-related consequences. The anterior (AIC) and posterior (PIC) insula play key, but distinct, roles in pain processing. Because insula dysregulation is implicated in both chronic pain and alcohol use disorder, we hypothesized alcohol intake would reduce pain-related insula activation and modulate pain-related functional connectivity, with subdivision-specific effects.
METHODS: N = 97 moderate drinkers (Mage = 26.1 years) completed double-blind laboratory sessions where they received alcohol (0.08 g/dL target BAC) or placebo. Then, T2∗-weighted BOLD fMRI was collected using a 3T MRI Scanner during heat pain stimulation. Repeated measures ANOVA characterized alcohol effects on AIC and PIC functional activation. Alcohol effects on pain-related FC were assessed using whole-brain generalized psychophysiological interaction (gPPI) analysis (pFDR<0.05).
RESULTS: Alcohol significantly decreased pain-related AIC activation, but increased PIC activation. Alcohol increased pain-related FC of AIC with bilateral postcentral gyrus, left precentral gyrus, and lateral occipital cortex. In contrast, alcohol increased FC of PIC with bilateral supramarginal gyrus, right frontal pole, right orbitofrontal cortex, right angular gyrus, and right middle frontal gyrus. Increased PIC FC with angular gyrus predicted greater subjective pain relief. FC with orbitofrontal gyrus was associated with reduced pain intensity.
CONCLUSION: Alcohol had subregion-specific effects on functional activation and FC during painful heat. Alcohol-induced changes in FC during heat pain were associated with pain relief and pain intensity. Our findings suggest an important contribution of the IC to alcohol's analgesic and pain-relieving effects.
METHODS: N = 97 moderate drinkers (Mage = 26.1 years) completed double-blind laboratory sessions where they received alcohol (0.08 g/dL target BAC) or placebo. Then, T2∗-weighted BOLD fMRI was collected using a 3T MRI Scanner during heat pain stimulation. Repeated measures ANOVA characterized alcohol effects on AIC and PIC functional activation. Alcohol effects on pain-related FC were assessed using whole-brain generalized psychophysiological interaction (gPPI) analysis (pFDR<0.05).
RESULTS: Alcohol significantly decreased pain-related AIC activation, but increased PIC activation. Alcohol increased pain-related FC of AIC with bilateral postcentral gyrus, left precentral gyrus, and lateral occipital cortex. In contrast, alcohol increased FC of PIC with bilateral supramarginal gyrus, right frontal pole, right orbitofrontal cortex, right angular gyrus, and right middle frontal gyrus. Increased PIC FC with angular gyrus predicted greater subjective pain relief. FC with orbitofrontal gyrus was associated with reduced pain intensity.
CONCLUSION: Alcohol had subregion-specific effects on functional activation and FC during painful heat. Alcohol-induced changes in FC during heat pain were associated with pain relief and pain intensity. Our findings suggest an important contribution of the IC to alcohol's analgesic and pain-relieving effects.