PloS one · 2026
Dietary inflammatory index in relation to incident CKD: A prospective study of UK Biobank participants.
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Yang Qian, Lin Queran, Liu Yixi, Bai Pufei, Gao Suhua, Lv Xin, Zhou Saijun, Liu Hongyan, Sun HaiZhen, Yu Pei
Аннотация
BACKGROUND AND OBJECTIVES: The relationship between increased inflammatory diet patterns and chronic kidney disease (CKD) remains unknown and has not been investigated in large cohorts.
METHODS: A total of 154,070 adults registered in UKB database were enrolled and followed, free of CKD and eGFR > 90 mL/min/1.73 m2 at baseline. The energy-adjusted dietary inflammatory index (E-DII) was evaluated using the 24-h recall diet. Cox proportional hazards regression models were used, adjusting for confounders such as demographic indicators, socioeconomic status, and lifestyle factors. Additionally, a subgroup analysis was conducted to investigate the relationship with incident CKD. The nonlinear relationship between E-DII and CKD risk was analyzed using a restricted cubic spline.
RESULTS: During a median follow-up of 11.4 years, 3402 (2.21%) cases occurred. After adjustment for all potential confounders, a higher E-DII was associated with an increased risk of incident CKD (HR for 1 unit increment: 1.05 (1.00-1.10), p = 0.034). According to the result of the restricted cubic spline, when E-DII > 1.857, the risk of early-stage CKD would increase significantly.
CONCLUSIONS: A higher pro-inflammatory diet was associated with an increased risk of early-stage CKD in the fully adjusted model. An anti-inflammatory diet may serve as a potential preventive strategy for early-stage CKD, although causal inference cannot be established from this observational study.
METHODS: A total of 154,070 adults registered in UKB database were enrolled and followed, free of CKD and eGFR > 90 mL/min/1.73 m2 at baseline. The energy-adjusted dietary inflammatory index (E-DII) was evaluated using the 24-h recall diet. Cox proportional hazards regression models were used, adjusting for confounders such as demographic indicators, socioeconomic status, and lifestyle factors. Additionally, a subgroup analysis was conducted to investigate the relationship with incident CKD. The nonlinear relationship between E-DII and CKD risk was analyzed using a restricted cubic spline.
RESULTS: During a median follow-up of 11.4 years, 3402 (2.21%) cases occurred. After adjustment for all potential confounders, a higher E-DII was associated with an increased risk of incident CKD (HR for 1 unit increment: 1.05 (1.00-1.10), p = 0.034). According to the result of the restricted cubic spline, when E-DII > 1.857, the risk of early-stage CKD would increase significantly.
CONCLUSIONS: A higher pro-inflammatory diet was associated with an increased risk of early-stage CKD in the fully adjusted model. An anti-inflammatory diet may serve as a potential preventive strategy for early-stage CKD, although causal inference cannot be established from this observational study.