Heart rhythm · 2025
Electrical and mechanical interventricular dyssynchrony coupling in patients with bradycardia: A UHF-ECG validation trial.
СтатьяВалидационное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Mizner Jan, Beela Ahmed, Linkova Hana, Vesela Jana, Sussenbek Ondrej, Stros Petr, Smisek Radovan, Jurak Pavel, Leinveber Pavel, Lipoldova Jolana, Nagy Andrej, Waldauf Petr, Lumens Joost, Vernooy Kevin, Prinzen Frits, Curila Karol
Аннотация
BACKGROUND: Ultra-high-frequency electrocardiography (UHF-ECG) is a noninvasive tool visualizing the ventricular activation sequence. It was never compared with other methods of dyssynchrony assessment in patients with bradycardia.
OBJECTIVE: We aimed to compare UHF-ECG interventricular electrical dyssynchrony (e-DYS) with interventricular mechanical delay (IVMD) measured by echocardiography in patients receiving right ventricular pacing (RVP) or conduction system pacing (CSP).
METHODS: Fifty-three patients with advanced atrioventricular conduction disease and preserved ventricular systolic function were prospectively assigned to RVP (n=32 [60 %]) or CSP (n=21 [40 %]). IVMD was measured as the time difference between left ventricular and right ventricular preejection periods. Interventricular e-DYS was calculated by software as the time difference between activation in V1 and V7 chest electrodes using UHF-ECG.
RESULTS: The median age of patients was 75 (interquartile range 72-80) years, and both groups had similar clinical characteristics. Baseline IVMD and interventricular e-DYS were similar in the entire population (-2 [-8 to 5] ms vs-1 [-6 to 5] ms, respectively; P=.52). Both methods showed the same dyssynchrony trends after pacemaker implantation; that is, while both IVMD and interventricular e-DYS increased in the RVP group (IVMD 28 [23-33] ms vs interventricular e-DYS 26 [19-33] ms; P=.99), they remained low in the CSP group (IVMD -7 [-16 to 2] ms vs interventricular e-DYS -5 [-12 to 2] ms; P=.91). There was a moderate overall correlation between IVMD and interventricular e-DYS for all studied ventricular rhythms (R=0.74).
CONCLUSION: UHF-ECG noninvasively expresses interventricular dyssynchrony from V7-V1 chest leads with similar results to echocardiography. RVP increases interventricular dyssynchrony, while CSP preserves synchronous ventricular activation.
OBJECTIVE: We aimed to compare UHF-ECG interventricular electrical dyssynchrony (e-DYS) with interventricular mechanical delay (IVMD) measured by echocardiography in patients receiving right ventricular pacing (RVP) or conduction system pacing (CSP).
METHODS: Fifty-three patients with advanced atrioventricular conduction disease and preserved ventricular systolic function were prospectively assigned to RVP (n=32 [60 %]) or CSP (n=21 [40 %]). IVMD was measured as the time difference between left ventricular and right ventricular preejection periods. Interventricular e-DYS was calculated by software as the time difference between activation in V1 and V7 chest electrodes using UHF-ECG.
RESULTS: The median age of patients was 75 (interquartile range 72-80) years, and both groups had similar clinical characteristics. Baseline IVMD and interventricular e-DYS were similar in the entire population (-2 [-8 to 5] ms vs-1 [-6 to 5] ms, respectively; P=.52). Both methods showed the same dyssynchrony trends after pacemaker implantation; that is, while both IVMD and interventricular e-DYS increased in the RVP group (IVMD 28 [23-33] ms vs interventricular e-DYS 26 [19-33] ms; P=.99), they remained low in the CSP group (IVMD -7 [-16 to 2] ms vs interventricular e-DYS -5 [-12 to 2] ms; P=.91). There was a moderate overall correlation between IVMD and interventricular e-DYS for all studied ventricular rhythms (R=0.74).
CONCLUSION: UHF-ECG noninvasively expresses interventricular dyssynchrony from V7-V1 chest leads with similar results to echocardiography. RVP increases interventricular dyssynchrony, while CSP preserves synchronous ventricular activation.