Nature neuroscience · 2025

Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex.

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Ossenkoppele Rik, Coomans Emma M, Apostolova Liana G, Baker Suzanne L, Barthel Henryk, Beach Thomas G, Benzinger Tammy L S, Betthauser Tobey, Bischof Gérard N, Bottlaender Michel, Bourgeat Pierick, den Braber Anouk, Brendel Matthias, Brickman Adam M, Cash David M, Carrillo Maria C, Coath William, Christian Bradley T, Dickerson Brad C, Dore Vincent, Drzezga Alexander, Feizpour Azadeh, van der Flier Wiesje M, Franzmeier Nicolai, Frisoni Giovanni B, Garibotto Valentina, van de Giessen Elsmarieke, Domingo-Gispert Juan, Gnoerich Johannes, Gu Yuna, Guan Yihui, Hanseeuw Bernard J, Harrison Theresa M, Jack Clifford R, Jaeger Elena, Jagust William J, Jansen Willemijn J, La Joie Renaud, Johnson Keith A, Johnson Sterling C, Kennedy Ian A, Kim Jun Pyo, van Laere Koen, Lagarde Julien, Lao Patrick, Luchsinger José A, Kern Silke, Kreisl William C, Malotaux Vincent, Malpetti Maura, Manly Jennifer J, Mao Xiaoxie, Mattsson-Carlgren Niklas, Mayo Clinic Study on Aging, Messerschmidt Konstantin, Minguillon Carolina, Mormino Elizabeth M, O'Brien John T, Palmqvist Sebastian, Peretti Debora E, Petersen Ron C, Pijnenburg Yolande A L, Pontecorvo Michael J, Poirier Judes, PREVENT-AD Research Group, Rabinovici Gil D, Rahmouni Nesrine, Risacher Shannon L, Rosa-Neto Pedro, Rosen Howard, Rowe Christopher C, Rowe James B, Rullmann Michael, Salman Yasmine, Sarazin Marie, Saykin Andrew J, Schneider Julie A, Schöll Michael, Schott Jonathan M, Seo Sang Won, Serrano Geidy E, Shcherbinin Sergey, Shekari Mahnaz, Skoog Ingmar, Smith Ruben, Sperling Reisa A, Spruyt Laure, Stomrud Erik, Strandberg Olof, Therriault Joseph, Xie Fang, Vandenberghe Rik, Villemagne Victor L, Villeneuve Sylvia, Visser Pieter Jelle, Vossler Hillary, Young Christina B, Groot Colin, Hansson Oskar

Аннотация

Tau positron emission tomography (PET) imaging allows in vivo detection of tau proteinopathy in Alzheimer's disease, which is associated with neurodegeneration and cognitive decline. Understanding how demographic, clinical and genetic factors relate to tau PET positivity will facilitate its use for clinical practice and research. Here we conducted an analysis of 42 cohorts worldwide (N = 12,048), including 7,394 cognitively unimpaired (CU) participants, 2,177 participants with mild cognitive impairment (MCI) and 2,477 participants with dementia. We found that from age 60 years to 80 years, tau PET positivity in a temporal composite region increased from 1.1% to 4.4% among CU amyloid-β (Aβ)-negative participants and from 17.4% to 22.2% among CU Aβ-positive participants. Across the same age span, tau PET positivity decreased from 68.0% to 52.9% in participants with MCI and from 91.5% to 74.6% in participants with dementia. Age, Aβ status, APOE ε4 carriership and female sex were all associated with a higher prevalence of tau PET positivity across groups. APOE ε4 carriership in CU individuals lowered the age at onset of both Aβ positivity and tau positivity by decades. Finally, we replicated these associations in an independent autopsy dataset (N = 5,072 from 3 cohorts).

Предметные рубрики MeSH

Humans Female Male Positron-Emission Tomography Amyloid beta-Peptides tau Proteins Aged Middle Aged Aged, 80 and over Cognitive Dysfunction Apolipoproteins E Genotype Age Factors Cohort Studies Sex Factors

Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex.

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Аннотация

Предметные рубрики MeSH