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DOI 10.1038/s41380-020-00967-1

Медицинская библиотека · Molecular psychiatry · 2020

Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis.

Wang Xin, Xie Hong, Chen Tian, Cotton Andrew S, Salminen Lauren E, Logue Mark W, Clarke-Rubright Emily K, Wall John, Dennis Emily L, O'Leary Brian M, Abdallah Chadi G, Andrew Elpiniki, Baugh Lee A, Bomyea Jessica, Bruce Steven E, Bryant Richard, Choi Kyle, Daniels Judith K, Davenport Nicholas D, Davidson Richard J, DeBellis Michael, deRoon-Cassini Terri, Disner Seth G, Fani Negar, Fercho Kelene A, Fitzgerald Jacklynn, Forster Gina L, Frijling Jessie L, Geuze Elbert, Gomaa Hassaan, Gordon Evan M, Grupe Dan, Harpaz-Rotem Ilan, Haswell Courtney C, Herzog Julia I, Hofmann David, Hollifield Michael, Hosseini Bobak, Hudson Anna R, Ipser Jonathan, Jahanshad Neda, Jovanovic Tanja, Kaufman Milissa L, King Anthony P, Koch Saskia B J, Koerte Inga K, Korgaonkar Mayuresh S, Krystal John H, Larson Christine, Lebois Lauren A M, Levy Ifat, Li Gen, Magnotta Vincent A, Manthey Antje, May Geoffrey, McLaughlin Katie A, Mueller Sven C, Nawijn Laura, Nelson Steven M, Neria Yuval, Nitschke Jack B, Olff Miranda, Olson Elizabeth A, Peverill Matthew, Phan K Luan, Rashid Faisal M, Ressler Kerry, Rosso Isabelle M, Sambrook Kelly, Schmahl Christian, Shenton Martha E, Sierk Anika, Simons Jeffrey S, Simons Raluca M, Sponheim Scott R, Stein Murray B, Stein Dan J, Stevens Jennifer S, Straube Thomas, Suarez-Jimenez Benjamin, Tamburrino Marijo, Thomopoulos Sophia I, van der Wee Nic J A, van der Werff Steven J A, van Erp Theo G M, van Rooij Sanne J H, van Zuiden Mirjam, Varkevisser Tim, Veltman Dick J, Vermeiren Robert R J M, Walter Henrik, Wang Li, Zhu Ye, Zhu Xi, Thompson Paul M, Morey Rajendra A, Liberzon Israel

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПоддержка правительства СШАПеревод в очереди

Аннотация

Studies of posttraumatic stress disorder (PTSD) report volume abnormalities in multiple regions of the cerebral cortex. However, findings for many regions, particularly regions outside commonly studied emotion-related prefrontal, insular, and limbic regions, are inconsistent and tentative. Also, few studies address the possibility that PTSD abnormalities may be confounded by comorbid depression. A mega-analysis investigating all cortical regions in a large sample of PTSD and control subjects can potentially provide new insight into these issues. Given this perspective, our group aggregated regional volumes data of 68 cortical regions across both hemispheres from 1379 PTSD patients to 2192 controls without PTSD after data were processed by 32 international laboratories using ENIGMA standardized procedures. We examined whether regional cortical volumes were different in PTSD vs. controls, were associated with posttraumatic stress symptom (PTSS) severity, or were affected by comorbid depression. Volumes of left and right lateral orbitofrontal gyri (LOFG), left superior temporal gyrus, and right insular, lingual and superior parietal gyri were significantly smaller, on average, in PTSD patients than controls (standardized coefficients = -0.111 to -0.068, FDR corrected P values < 0.039) and were significantly negatively correlated with PTSS severity. After adjusting for depression symptoms, the PTSD findings in left and right LOFG remained significant. These findings indicate that cortical volumes in PTSD patients are smaller in prefrontal regulatory regions, as well as in broader emotion and sensory processing cortical regions.

Для цитирования: Wang Xin, Xie Hong, Chen Tian, Cotton Andrew S, Salminen Lauren E, Logue Mark W, Clarke-Rubright Emily K, Wall John, Dennis Emily L, O'Leary Brian M, Abdallah Chadi G, Andrew Elpiniki, Baugh Lee A, Bomyea Jessica, Bruce Steven E, Bryant Richard, Choi Kyle, Daniels Judith K, Davenport Nicholas D, Davidson Richard J, DeBellis Michael, deRoon-Cassini Terri, Disner Seth G, Fani Negar, Fercho Kelene A, Fitzgerald Jacklynn, Forster Gina L, Frijling Jessie L, Geuze Elbert, Gomaa Hassaan, Gordon Evan M, Grupe Dan, Harpaz-Rotem Ilan, Haswell Courtney C, Herzog Julia I, Hofmann David, Hollifield Michael, Hosseini Bobak, Hudson Anna R, Ipser Jonathan, Jahanshad Neda, Jovanovic Tanja, Kaufman Milissa L, King Anthony P, Koch Saskia B J, Koerte Inga K, Korgaonkar Mayuresh S, Krystal John H, Larson Christine, Lebois Lauren A M, Levy Ifat, Li Gen, Magnotta Vincent A, Manthey Antje, May Geoffrey, McLaughlin Katie A, Mueller Sven C, Nawijn Laura, Nelson Steven M, Neria Yuval, Nitschke Jack B, Olff Miranda, Olson Elizabeth A, Peverill Matthew, Phan K Luan, Rashid Faisal M, Ressler Kerry, Rosso Isabelle M, Sambrook Kelly, Schmahl Christian, Shenton Martha E, Sierk Anika, Simons Jeffrey S, Simons Raluca M, Sponheim Scott R, Stein Murray B, Stein Dan J, Stevens Jennifer S, Straube Thomas, Suarez-Jimenez Benjamin, Tamburrino Marijo, Thomopoulos Sophia I, van der Wee Nic J A, van der Werff Steven J A, van Erp Theo G M, van Rooij Sanne J H, van Zuiden Mirjam, Varkevisser Tim, Veltman Dick J, Vermeiren Robert R J M, Walter Henrik, Wang Li, Zhu Ye, Zhu Xi, Thompson Paul M, Morey Rajendra A, Liberzon Israel. Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis.. Molecular psychiatry. 2020. DOI: 10.1038/s41380-020-00967-1.

Предметные рубрики MeSH

Cerebral CortexGenomicsHumansMagnetic Resonance ImagingStress Disorders, Post-TraumaticTemporal Lobe
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