Transplantation proceedings · 2012
Clinical characteristics and outcomes of renal transplantation in elderly recipients.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Nanmoku K, Matsuda Y, Yamamoto T, Tsujita M, Hiramitsu T, Goto N, Katayama A, Watarai Y, Kobayashi T, Uchida K
Аннотация
BACKGROUND: Elderly renal transplant candidates constitute one the fastest-growing populations among end-stage renal disease patients. Since the impacts of advanced recipient age have not yet been fully defined, we evaluated the clinical characteristics and outcomes of elderly renal transplant recipients.
METHODS: Among 564 adult renal transplant recipients, at our center between 2000 and 2009, 64 were at least 60 years of age (Elderly group), and 500 were younger than 60 years (Young group) at the time of the procedure. We compared their clinical features and surgical management.
RESULTS: There were significant differences in mean donor age (55.6 years vs. 53.2 years, P = .030) and gender mismatch (77.0% vs. 63.4%, P = .035). However, there were no significant differences between the two groups in patient and graft survivals (P = .177 and P = .365, respectively). Malignancy after transplantation was a significant risk factor upon univariate evaluation but only ABO incompatibility upon multivariate analysis of patient and graft survival. The main cause of graft loss among the Elderly group was death with a functioning graft due to heart failure.
CONCLUSIONS: Renal transplantation is a feasible, safe option for the elderly and should be actively implemented. However, screening for cancer and heart disease should be mandatory to improve outcomes.
METHODS: Among 564 adult renal transplant recipients, at our center between 2000 and 2009, 64 were at least 60 years of age (Elderly group), and 500 were younger than 60 years (Young group) at the time of the procedure. We compared their clinical features and surgical management.
RESULTS: There were significant differences in mean donor age (55.6 years vs. 53.2 years, P = .030) and gender mismatch (77.0% vs. 63.4%, P = .035). However, there were no significant differences between the two groups in patient and graft survivals (P = .177 and P = .365, respectively). Malignancy after transplantation was a significant risk factor upon univariate evaluation but only ABO incompatibility upon multivariate analysis of patient and graft survival. The main cause of graft loss among the Elderly group was death with a functioning graft due to heart failure.
CONCLUSIONS: Renal transplantation is a feasible, safe option for the elderly and should be actively implemented. However, screening for cancer and heart disease should be mandatory to improve outcomes.
Предметные рубрики MeSH
ABO Blood-Group SystemAdolescentAdultAge FactorsAgedBlood Group IncompatibilityChi-Square DistributionFemaleGraft RejectionGraft SurvivalHeart FailureHistocompatibilityHumansImmunosuppressive AgentsJapanKaplan-Meier EstimateKidney Failure, ChronicKidney TransplantationMaleMiddle AgedMultivariate AnalysisNeoplasmsPatient SelectionProportional Hazards ModelsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeYoung Adult