Ancient genomes reveal a deep history of Treponema pallidum in the Americas.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Barquera Rodrigo, Sitter T Lesley, Kirkpatrick Casey L, Ramirez Darío A, Kocher Arthur, Spyrou Maria A, Couoh Lourdes R, Talavera-González Jorge A, Castro Mario, von Hunnius Tanya, Guevara Evelyn K, Hamilton W Derek, Roberts Patrick, Scott Erin, Fabra Mariana, Da Peña Gabriela V, Pacheco Aryel, Rodriguez Mónica, Aspillaga Eugenio, Tiliakou Anthi, Nelson Elizabeth A, Giffin Karen L, Bianco Raffaela A, Rohrlach Adam B, de Los Ángeles García Martínez María, Ballesteros Solís Fabiola A, Sajantila Antti, Saunders Shelley R, Nores Rodrigo, Herbig Alexander, Krause Johannes, Bos Kirsten I
Аннотация
Human treponemal infections are caused by a family of closely related Treponema pallidum that give rise to the diseases yaws, bejel, pinta and, most notably, syphilis1. Debates on a common origin for these pathogens and the history of syphilis itself have weighed evidence for the 'Columbian hypothesis'2, which argues for an American origin, against that for the 'pre-Columbian hypothesis'3, which argues for the presence of the disease in Eurasia in the Medieval period and possibly earlier. Although molecular data has provided a genetic basis for distinction of the typed subspecies4, deep evolution of the complex has remained unresolved owing to limitations in the conclusions that can be drawn from the sparse palaeogenomic data that are currently available. Here we explore this evolutionary history through analyses of five pre- and peri-contact ancient treponemal genomes from the Americas that represent ancient relatives of the T. pallidum subsp. pallidum (syphilis), T. pallidum subsp. pertenue (yaws) and T. pallidum subsp. endemicum (bejel) lineages. Our data indicate unexplored diversity and an emergence of T. pallidum that post-dates human occupation in the Americas. Together, these results support an American origin for all T. pallidum characterized at the genomic level, both modern and ancient.