The Role of Hybrid PET-MRI in the Diagnosis and Management of Cardiac Sarcoidosis-A Narrative Review.

Background/Objectives: Cardiac involvement in sarcoidosis necessitates meticulous management, with accurate and timely diagnosis being crucial. The hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) modality is an emerging diagnostic tool for cardiac sarcoidosis, offering potential advantages over the use of independent PET and MRI techniques for both diagnosis and prognosis. Methods: Following the PRISMA guidelines for study selection, a comprehensive search using the terms "hybrid PET/MRI" and/or "cardiac sarcoidosis" identified a total of 10 eligible studies. Results: Patients were primarily middle-aged males. Overall, hybrid PET/MR enhanced diagnostic accuracy by identifying specific subgroups, detecting active disease, enabling detailed quantitative analysis, and assessing regional involvement. Additionally, it offered valuable insights that could improve phenotyping and prognostic predictions. The primary limitation was the longer duration of a single scan; however, the total scanning time was reduced compared to conducting two separate procedures. Conclusions: Hybrid PET/MR imaging offers several significant advantages over separate imaging modalities when diagnosing cardiac sarcoidosis, including increased diagnostic accuracy and comprehensive tissue characterization. Further comparative studies are needed to fully understand its clinical impact and potential limitations.