International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
A new hepatitis delta virus hotspot in Ethiopia: A multicenter study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Simbo Teklu Shiferaw, Schlund Franziska, Gal Frédéric Le, Gerber Athenais, Zheng Sezen, Abegaz Woldaregay Erku, Negash Abel Abera, Gudisa Fikadu Girma, Birhanu Dawit, Hussen Ahmed, Cheneke Waqtola, Gudina Esayas Kebede, Nkongolo Shirin, Lempp Florian A, Berhe Nega, Mekonnen Hailemichael Desalegn, Rossvoll Lasse, Urban Stephan, Johannessen Asgeir
Аннотация
OBJECTIVES: Ethiopia is endemic for hepatitis B virus (HBV), but co-infection with hepatitis D virus (HDV) is considered uncommon. We investigated HDV prevalence and its clinical implications among HBV-infected individuals in various regions of Ethiopia.
METHODS: A cross-sectional study was conducted among 5383 hepatitis B surface antigen-positive adults at four HBV treatment centers from December 2021 to December 2023. Anti-HDV was analyzed using an Enzyme-Linked Immunosorbent Assay method, and HDV RNA using a quantitative PCR assay. Kruskal-Wallis rank sum tests were used to compare liver injury markers.
RESULTS: Anti-HDV seroprevalence was low in Jigjiga (11/1003; 1.1%), Adama (68/2167; 3.1%), and Jimma (40/890; 4.5%), but high in Dubti (248/1323; 18.7%). Corresponding viremic HDV infection was 2/1003 (0.2%), 23/2166 (1.1%), 10/889 (1.1%), and 161/1322 (12.2%), respectively. All the sequenced HDV strains were genotype 1. HDV RNA-positive individuals had higher median alanine aminotransferase (51 vs 32 vs 25 U/L, P < 0.001), aspartate aminotransferase (AST) (49 vs 32 vs 26 U/L, P < 0.001), AST-to-platelet ratio index (0.55 vs 0.36 vs 0.28, P < 0.001) and liver stiffness (8.1 vs 5.7 vs 5.2 kPa, P < 0.001) compared to anti-HDV-positive HDV RNA-negative and anti-HDV-negative patients.
CONCLUSION: The Afar region of Ethiopia is a hotspot for HDV infection, challenging the notion that HDV is uncommon in East Africa.
METHODS: A cross-sectional study was conducted among 5383 hepatitis B surface antigen-positive adults at four HBV treatment centers from December 2021 to December 2023. Anti-HDV was analyzed using an Enzyme-Linked Immunosorbent Assay method, and HDV RNA using a quantitative PCR assay. Kruskal-Wallis rank sum tests were used to compare liver injury markers.
RESULTS: Anti-HDV seroprevalence was low in Jigjiga (11/1003; 1.1%), Adama (68/2167; 3.1%), and Jimma (40/890; 4.5%), but high in Dubti (248/1323; 18.7%). Corresponding viremic HDV infection was 2/1003 (0.2%), 23/2166 (1.1%), 10/889 (1.1%), and 161/1322 (12.2%), respectively. All the sequenced HDV strains were genotype 1. HDV RNA-positive individuals had higher median alanine aminotransferase (51 vs 32 vs 25 U/L, P < 0.001), aspartate aminotransferase (AST) (49 vs 32 vs 26 U/L, P < 0.001), AST-to-platelet ratio index (0.55 vs 0.36 vs 0.28, P < 0.001) and liver stiffness (8.1 vs 5.7 vs 5.2 kPa, P < 0.001) compared to anti-HDV-positive HDV RNA-negative and anti-HDV-negative patients.
CONCLUSION: The Afar region of Ethiopia is a hotspot for HDV infection, challenging the notion that HDV is uncommon in East Africa.