[Evaluation of the relationship between concentration of serotonin in plasma and blood platelets and hypertension in women chronically exposed to carbon disulfide].

Totally 140 women, aged 25-50 years, were examined clinically. They were divided into two groups. Group I, the controls, (n - 50; mean age 40.1 +/- 8.7) not exposed to carbon disulfide, and Group II (n = 90; mean age 39.7 +/- 9.1) exposed to carbon disulphide at concentration of 9.36-23.4 mg/m3. Concentration of serotonin in plasma and blood platelets was determined using Manuchin's colorimetric method. Student t-test and the Pearson linear correlation coefficient "C" were used for statistical analysis. It was found that women chronically exposed to carbon disulfide showed significantly higher values of serotonin concentration in plasma and thrombocytes (p < 0.001) that the controls. Also positive linear correlation was noted between concentration of serotonin and hypertension in women exposed to CS2.