Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
Resistance and resilience to Alzheimer's disease in Down syndrome.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Boyle Rory, Koops Elouise A, Ances Beau, Andrews Elizabeth J, Arenaza-Urquijo Eider M, Bejanin Alexandre, Brickman Adam M, Buckley Rachel F, Clas Giulia S, Costello Emmet, Coughlan Gillian T, Conley Alexander C, Deng Feng, de Paula Faria Daniele, Edwards Natalie, Flores-Aguilar Lisi, Fortea Juan, Ghazi Saidi Ladan, Head Elizabeth, Hom Christy L, Koenig Katherine, Lao Patrick, Lengyel Imre, Li Yi-Ju, Loi Samantha, Loughrey David, McGlinchey Eimear, Newhouse Paul, Pertierra Lucía, Prokopiou Prokopis C, Qi Qing, de Paula França Resende Elisa, Russell Jason, Scanlon Catherine E, Schneider Christoph, Schultz Stephanie A, Seto Mabel, Shaka Sophia, Soldan Anja, Vaqué Alcázar Lídia, Weng Yihe, Wilson Jo Ellen, Zaman Shahid H, Zsadányi Sára E, Hartley Sigan
Аннотация
Due to the high prevalence of Alzheimer's disease (AD) in adults with Down syndrome (DS), trisomy 21 is now considered a genetic form of AD (DSAD). A better understanding of factors that can prevent or delay AD is vital to improve outcomes for adults with DS. In this narrative review, we apply AD and cognitive aging research frameworks to study resistance and resilience in DSAD. Given the variability in the timing of pathology and symptoms, we discuss the evidence supporting the role of genetic, biological, socio-behavioral, lifestyle, and environmental factors in resistance and resilience to DSAD. We also consider how co-occurring health conditions in DS may influence resistance and resilience, and how methods from AD research can be applied to DSAD. Ultimately, this framework aims to guide future research and translate findings into clinical interventions to improve outcomes in DSAD. Highlights Definitions of resistance and resilience in the genetic form of Alzheimer's disease (DSAD) are proposed for guiding the field. Variability in the timing of AD pathology and symptoms suggests the potential for resistance and resilience mechanisms in DSAD. Genetic, biological, socio-behavioral, lifestyle, and environmental factors have the potential to build resistance or resilience in DSAD. Future research will require longitudinal and experimental designs, life course approaches, and large cohort studies.