Heart rhythm O2 · 2025
Arrhythmia substrate identification using wideband motion-corrected late gadolinium enhancement magnetic resonance imaging in a swine model of myocardial infarction with taped implantable cardioverter-defibrillators.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Sheagren Calder D, Escartin Terenz, Patel Jaykumar H, Barry Jennifer, Chow Kelvin, Bi Xiaoming, Terricabras Maria, Wright Graham A
Аннотация
BACKGROUND: Sudden cardiac death is a leading worldwide cause of cardiac mortality and is largely related to ventricular tachycardia (VT) in patients with known myocardial scarring. In these patients, implantable cardioverter-defibrillator (ICD) therapy reduces arrhythmia-related mortality. However, curative procedures such as catheter ablation are used to homogenize regions of scar and remove structural re-entry circuits that cause VT.
OBJECTIVE: In this paper, we conduct a preliminary experiment comparing 2-dimensional (2D) late gadolinium enhancement (LGE) and 3-dimensional (3D) LGE without an ICD with wideband motion-corrected (WB-MOCO) LGE with an ICD in a cohort of infarcted Yorkshire swine.
METHODS: Animals were imaged after infarct with conventional 2D and 3D LGE without an ICD present and 2D WB-MOCO LGE with an ICD present. Images were analyzed to determine heterogeneous tissue corridor (HTC) count and location, which were compared with circuit exit locations determined using a 12-lead electrocardiogram.
RESULTS: We found a statistically significant increase in HTC count with WB-MOCO LGE, but no significant differences in the number of true-positive or false-positive HTCs per subject.
CONCLUSION: WB-MOCO LGE has reduced specificity to physiologically relevant HTCs than conventional 2D or 3D LGE.
OBJECTIVE: In this paper, we conduct a preliminary experiment comparing 2-dimensional (2D) late gadolinium enhancement (LGE) and 3-dimensional (3D) LGE without an ICD with wideband motion-corrected (WB-MOCO) LGE with an ICD in a cohort of infarcted Yorkshire swine.
METHODS: Animals were imaged after infarct with conventional 2D and 3D LGE without an ICD present and 2D WB-MOCO LGE with an ICD present. Images were analyzed to determine heterogeneous tissue corridor (HTC) count and location, which were compared with circuit exit locations determined using a 12-lead electrocardiogram.
RESULTS: We found a statistically significant increase in HTC count with WB-MOCO LGE, but no significant differences in the number of true-positive or false-positive HTCs per subject.
CONCLUSION: WB-MOCO LGE has reduced specificity to physiologically relevant HTCs than conventional 2D or 3D LGE.