A Perfect Storm: Pulmonary Edema Following Misoprostol Administration in the Midst of Sepsis, Pneumonia, and Retained Pregnancy: A Rare Case Report.

Pulmonary edema is a rare but serious event that can occur in critically ill obstetric patients with multiple comorbidities. This case describes its occurrence following misoprostol administration in a highly vulnerable patient with sepsis, preeclampsia, and intrauterine fetal demise. While a temporal association was observed, causation cannot be definitively established. This report highlights the importance of vigilant monitoring and readiness for advanced respiratory support when using uterotonics in high-risk, destabilized patients. It is crucial to emphasize that misoprostol remains a safe and lifesaving medication for the vast majority of obstetric patients, and this unique case should not deter its essential use.