Immunochemical Markers and Quality of Life in Severe Atopic Dermatitis: A Real-World Analysis.
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Agarwal Ashok, Farkouh Ala'a, Saleh Ramadan, Hamoda Taha Abo-Almagd Abdel-Meguid, Salvio Gianmaria, Boitrelle Florence, Harraz Ahmed M, Ghayda Ramy Abou, Kavoussi Parviz, Gül Murat, Toprak Tuncay, Russo Giorgio Ivan, Durairajanayagam Damayanthi, Rambhatla Amarnath, Birowo Ponco, Cannarella Rossella, Phuoc Nguyen Ho Vinh, Zini Armand, Arafa Mohamed, Wyns Christine, Tremellen Kelton, Sarıkaya Selçuk, Lewis Sheena, Evenson Donald P, Ko Edmund, Calogero Aldo E, Bahar Fahmi, Martínez Marlon, Ambar Rafael F, Colpi Giovanni M, Bakircioglu Mustafa Emre, Henkel Ralf, Kandil Hussein, Serefoglu Ege Can, Alfakhri Abdullah, Tsujimura Akira, Kheradmand Alireza, Marino Angelo, Adamyan Aram, Zilaitiene Birute, Ozer Cevahir, Pescatori Edoardo, Vogiatzi Paraskevi, Busetto Gian Maria, Balercia Giancarlo, Elbardisi Haitham, Akhavizadegan Hamed, Sajadi Hesamoddin, Taniguchi Hisanori, Park Hyun Jun, Maldonado Rosas Israel, Al-Marhoon Mohamed, Sadighi Gilani Mohammad Ali, Alhathal Naif, Quang Nguyen, Pinggera Germar-Michael, Kothari Priyank, Micic Sava, Homa Sheryl, Long Tran Quang Tien, Zohdy Wael, Atmoko Widi, Ibrahim Wael, Sabbaghian Marjan, Abumelha Saad Mohammed, Chung Eric, Ugur Muhammet Rasit, Ozkent Mehmet Serkan, Selim Osama, Darbandi Mahsa, Fukuhara Shinichiro, Jamali Mounir, de la Rosette Jean, Kuroda Shinnosuke, Smith Ryan P, Baser Aykut, Kalkanli Arif, Tadros Nicholas N, Aydos Kaan, Mierzwa Tiago Cesar, Khalafalla Kareim, Malhotra Vineet, Moussa Mohamad, Finocchi Federica, Rachman Rinaldo Indra, Giulioni Carlo, Avidor-Reiss Tomer, Kahraman Oguzhan, Çeker Gökhan, Zenoaga-Barbăroșie Cătălina, Barrett Trenton L, Yilmaz Mehmet, Kadioglu Ates, Jindal Sunil, Omran Huda, Bocu Kadir, Karthikeyan Vilvapathy Senguttuvan, Franco Giorgio, Solorzano Jesús Fernando, Vishwakarma Ranjit B, Arianto Eko, Garrido Nicolas, Jain Divyanu, Gherabi Nazim, Sokolakis Ioannis, Palani Ayad, Calik Gokhan, Kulaksiz Deniz, Simanaviciene Vaida, Simopoulou Mara, Güngör Nur Dokuzeylül, Blecher Gideon, Falcone Marco, Jezek Davor, Preto Mirko, Amar Edouard, Le Tan V, Ahn Sun Tae, Rezano Andri, Singh Keerti, Rocco Lucia, Savira Missy, Rajmil Osvaldo, Darbandi Sara, Sogutdelen Emrullah, Boeri Luca, Hernández Guadalupe, Hakim Lukman, Morimoto Yoshiharu, Japari Andrian, Sofikitis Nikolaos, Altay Baris, Metin Mahmutoglu Asli, Al Hashimi Manaf, Ziouziou Imad, Anagnostopoulou Christina, Lin Haocheng, Shah Rupin
Аннотация
MATERIALS AND METHODS: Clinicians managing male infertility were invited to complete an online survey on practices related to SDF diagnostic and treatment approaches. Their responses related to the technical aspects of SDF testing, current professional society guidelines, and the literature were used to generate expert recommendations via the Delphi method. Finally, challenges related to SDF that the clinicians encounter in their daily practice were captured.
RESULTS: The survey was completed by 436 reproductive clinicians. Overall, terminal deoxynucleotidyl transferase deoxyuridine triphosphate Nick-End Labeling (TUNEL) is the most commonly used assay chosen by 28.6%, followed by the sperm chromatin structure assay (24.1%), and the sperm chromatin dispersion (19.1%). The choice of the assay was largely influenced by availability (70% of respondents). A threshold of 30% was the most selected cut-off value for elevated SDF by 33.7% of clinicians. Of respondents, 53.6% recommend SDF testing after 3 to 5 days of abstinence. Although 75.3% believe SDF testing can provide an explanation for many unknown causes of infertility, the main limiting factors selected by respondents are a lack of professional society guideline recommendations (62.7%) and an absence of globally accepted references for SDF interpretation (50.3%).
CONCLUSIONS: This study represents the largest global survey on the technical aspects of SDF testing as well as the barriers encountered by clinicians. Unified global recommendations regarding clinician implementation and standard laboratory interpretation of SDF testing are crucial.