MedElevator Войти в исследования
← Поиск публикаций

DOI 10.1038/s41467-026-73519-w

Медицинская библиотека · Nature communications · 2026

Very low-carbohydrate ketogenic diet in treatment-naïve women with endometrial cancer and overweight: a randomized feasibility study.

Dantas Ezequiel, Hootman Katie C, Moyer Jenna, Tomberlin Morgan, Curran Katherine, Ramesh Bhavani, Price Hannah, Kim Jeshua, McPherson Alex C, Hurd Maurice A, Zhu Yuan-Shan, Plodkowski Andrew J, Nagase Erica, Tsomides Anastasia, Cuevas Brandon M, Martin M Laura, Nguyen John, Bennetti Gabrielle, Rodriguez Gissell Botero, Chang Kaity, Mezzancello Marissa, Gardner Ginger J, Broach Vance, Mueller Jennifer J, Sonoda Yukio, Zivanovic Oliver, Leitao Mario M, Iasonos Alexia, Soldan Krysten, Carthew Karen, Hom Vania, Villamater Francis N, Chaari Rema Rao, Gorski Kathryn, Sigouros Michael, Aghajanian Carol, Elemento Olivier, Cantley Lewis C, Hopkins Benjamin D, Weigelt Britta, Ellenson Lora H, Hacker Kari, Abu-Rustum Nadeem R, Makker Vicky, Goncalves Marcus D

СтатьяРандомизированное исследованиеМногоцентровое исследованиеПеревод в очереди

Аннотация

This multicenter, prospective, randomized controlled trial (NCT03285152) evaluates the primary endpoint of feasibility of a very-low carbohydrate diet (VLCD) in 19 women with obesity/overweight and endometrial cancer, who are randomized 2:1 to either a VLCD or a standard diet for 21-28 days. Fifteen participants complete the study, with 91 ± 4% of VLCD meals consumed, 5.5 ± 0.8% weight lost, and no grade 3/4 adverse events. Secondary endpoints include assessments of tumor biology and circulating metabolic biomarkers. Fasting glucose and insulin fall 22 ± 5.9% and 60 ± 3.8%, while total cholesterol and low-density lipoprotein (LDL) rise 6 ± 2.7% and 17.8 ± 8.9%. In a pre-specified exploratory outcome, RNA-Seq shows enrichment of CD8 + T-cells (q < 0.034; NES > 1.75), confirmed by immunohistochemistry (IHC) showing CD8 + T-cells infiltration of the tumor margins (q = 0.034; NES = 1.75). We conclude that VLCD is feasible and well-tolerated.

Для цитирования: Dantas Ezequiel, Hootman Katie C, Moyer Jenna, Tomberlin Morgan, Curran Katherine, Ramesh Bhavani, Price Hannah, Kim Jeshua, McPherson Alex C, Hurd Maurice A, Zhu Yuan-Shan, Plodkowski Andrew J, Nagase Erica, Tsomides Anastasia, Cuevas Brandon M, Martin M Laura, Nguyen John, Bennetti Gabrielle, Rodriguez Gissell Botero, Chang Kaity, Mezzancello Marissa, Gardner Ginger J, Broach Vance, Mueller Jennifer J, Sonoda Yukio, Zivanovic Oliver, Leitao Mario M, Iasonos Alexia, Soldan Krysten, Carthew Karen, Hom Vania, Villamater Francis N, Chaari Rema Rao, Gorski Kathryn, Sigouros Michael, Aghajanian Carol, Elemento Olivier, Cantley Lewis C, Hopkins Benjamin D, Weigelt Britta, Ellenson Lora H, Hacker Kari, Abu-Rustum Nadeem R, Makker Vicky, Goncalves Marcus D. Very low-carbohydrate ketogenic diet in treatment-naïve women with endometrial cancer and overweight: a randomized feasibility study.. Nature communications. 2026. DOI: 10.1038/s41467-026-73519-w.

Предметные рубрики MeSH

HumansFemaleEndometrial NeoplasmsMiddle AgedFeasibility StudiesDiet, KetogenicOverweightDiet, Carbohydrate-RestrictedCD8-Positive T-LymphocytesObesityProspective StudiesBlood GlucoseAgedInsulin
Подготовка и перевод публикации
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.