Sheng wu gong cheng xue bao = Chinese journal of biotechnology · 2024
[Effects of inhibitors of DNA repair enzymes OGG1 and MTH1 on the replication of African swine fever virus].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Zhang Xiaoqiang, Fan Jie, Yang Jifei, Fu Jingsheng, Wu Mengli, Shao Chengxiang, Guan Guiquan, Yin Hong, Liu Zhijie, Niu Qingli
Аннотация
African swine fever virus (ASFV), as a contagious viral pathogen, is responsible for the occurrence of African swine fever (ASF), a rapidly spreading and highly lethal disease. Since ASFV was introduced into China in 2018, it has been quickly spread to many provinces, which brought great challenges to the pig industry in China. Due to the limited knowledge about the pathogenesis of ASFV, neither vaccines nor antiviral drugs are available. We have found that ASFV infection can induce oxidative stress responses in cells, and DNA repair enzymes play a key role in this process. This study employed RNA interference, RT-qPCR, Western blotting, Hemadsorption (HAD), and flow cytometry to investigate the effects of the inhibitors of DNA repair enzymes OGG1 and MTH1 on ASFV replication and evaluated the anti-ASFV effects of the inhibitors. This study provides reference for the development of anti-viral drugs.