Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2025
Feasibility and Efficacy of Cell-Free Ascites Reinfusion Therapy for Pseudomyxoma Peritonei: A Single-Center, Retrospective Study.
СтатьяНазвание и аннотация: Перевод в очереди
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Kaneko Takahiro, Otake Yuki, Katagiri Daisuke, Nunose Naoto, Suzuki Minami, Fukaya Takashi, Takano Hideki, Gohda Yoshimasa, Kojima Yasushi
Аннотация
INTRODUCTION: Limited treatments are available for the highly mucinous Pseudomyxoma Peritonei (PMP)-related ascites. This study assessed the feasibility and efficacy of cell-free ascites reinfusion therapy (CART) for PMP-related ascites.
METHODS: Patients with PMP who underwent CART between 2017 and 2021 were included. We retrospectively collected clinical data and compared pre- and post-CART clinical features and symptoms.
RESULTS: Nine patients with PMP underwent 12 CART sessions. A wild-bore chest tube was used in 25% (3/12) of sessions, with no severe complications. Abdominal pain and food intake improved in 92% (11/12) and 42% (5/12) of sessions, respectively (median decrease in weight, -4.4 kg [p = 0.02]). Serum albumin and creatinine levels did not change significantly (p = 0.280 vs. p > 0.500). Mild fever occurred during or after CART in 67% (9/12) of sessions; severe complications were not observed.
CONCLUSION: CART may be a relatively safe and affordable treatment for PMP-related ascites.
METHODS: Patients with PMP who underwent CART between 2017 and 2021 were included. We retrospectively collected clinical data and compared pre- and post-CART clinical features and symptoms.
RESULTS: Nine patients with PMP underwent 12 CART sessions. A wild-bore chest tube was used in 25% (3/12) of sessions, with no severe complications. Abdominal pain and food intake improved in 92% (11/12) and 42% (5/12) of sessions, respectively (median decrease in weight, -4.4 kg [p = 0.02]). Serum albumin and creatinine levels did not change significantly (p = 0.280 vs. p > 0.500). Mild fever occurred during or after CART in 67% (9/12) of sessions; severe complications were not observed.
CONCLUSION: CART may be a relatively safe and affordable treatment for PMP-related ascites.