Acta clinica Belgica · 2026
Clinicopathologic characteristics and long-term outcomes in glomerulonephritis with crescent formation: a 20-year single-center cohort study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Yılmaz Tugay, Döngelli Hüseyin, Oktan Mehmet Ası, Heybeli Cihan, Deligöz Bildacı Yelda, Korucu Berfu, Atay İlker, Çavdar Caner, Değer Serpil Müge
Аннотация
INTRODUCTION: Crescentic glomerulonephritis (GN) is among the most aggressive glomerular diseases, defined by extensive crescent formation and rapid loss of kidney function.
OBJECTIVE: To evaluate clinical, laboratory, and histopathologic determinants of end-stage kidney disease (ESKD) and overall survival (OS), and to identify associated factors of poor outcomes in patients with crescentic GN (cGN) and GN with crescent formation.
METHODS: This single-center retrospective cohort included 194 adults who underwent kidney biopsy between 2005 and 2024. The primary endpoints were progression to ESKD and OS. Cox proportional hazards and Kaplan - Meier analyses were performed.
RESULTS: Immune complex GN was the predominant subtype (59.3%), followed by pauci-immune GN (38.1%) and anti-GBM disease (2.6%). cGN accounted for 25.2% of cases. Overall, 42.8% of patients progressed to ESKD, while 35.6% died during follow-up. In multivariate Cox analysis, maintenance steroid monotherapy was a strong independent associated factor of ESKD (HR 2.349, 95% CI 1.378-4.004, p = 0.002), along with baseline creatinine (HR 1.180, 95% CI 1.023-1.360, p = 0.023), proteinuria (HR 1.067, 95% CI 1.020-1.117, p = 0.005), global glomerulosclerosis (HR 4.103, 95% CI 1.083-15.540, p = 0.038), and IgA positivity (HR 0.758, 95% CI 0.587-0.979, p = 0.034). For OS, steroid monotherapy remained independently associated with mortality (HR 2.427, 95% CI 1.370-4.299, p = 0.002), along with older age and reduced eGFR.
CONCLUSION: Maintenance steroid monotherapy was the strongest treatment-related factor associated with both ESKD and overall survival, highlighting the potential risks of inadequate maintenance immunosuppression in high-risk patients.
OBJECTIVE: To evaluate clinical, laboratory, and histopathologic determinants of end-stage kidney disease (ESKD) and overall survival (OS), and to identify associated factors of poor outcomes in patients with crescentic GN (cGN) and GN with crescent formation.
METHODS: This single-center retrospective cohort included 194 adults who underwent kidney biopsy between 2005 and 2024. The primary endpoints were progression to ESKD and OS. Cox proportional hazards and Kaplan - Meier analyses were performed.
RESULTS: Immune complex GN was the predominant subtype (59.3%), followed by pauci-immune GN (38.1%) and anti-GBM disease (2.6%). cGN accounted for 25.2% of cases. Overall, 42.8% of patients progressed to ESKD, while 35.6% died during follow-up. In multivariate Cox analysis, maintenance steroid monotherapy was a strong independent associated factor of ESKD (HR 2.349, 95% CI 1.378-4.004, p = 0.002), along with baseline creatinine (HR 1.180, 95% CI 1.023-1.360, p = 0.023), proteinuria (HR 1.067, 95% CI 1.020-1.117, p = 0.005), global glomerulosclerosis (HR 4.103, 95% CI 1.083-15.540, p = 0.038), and IgA positivity (HR 0.758, 95% CI 0.587-0.979, p = 0.034). For OS, steroid monotherapy remained independently associated with mortality (HR 2.427, 95% CI 1.370-4.299, p = 0.002), along with older age and reduced eGFR.
CONCLUSION: Maintenance steroid monotherapy was the strongest treatment-related factor associated with both ESKD and overall survival, highlighting the potential risks of inadequate maintenance immunosuppression in high-risk patients.