Multiple sclerosis (Houndmills, Basingstoke, England) · 2026
Prescription drug dispensations 15 years before multiple sclerosis onset: A matched cohort study, British Columbia, Canada.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ruiz-Algueró Marta, Ahmed Seid Mussa, Zhu Feng, Zhao Yinshan, Marrie Ruth Ann, Tremlett Helen
Аннотация
BACKGROUND: Few studies assessed drug dispensations for periods >5 years pre-multiple sclerosis (MS) onset or examined the time pre-MS symptom onset.
OBJECTIVE: The objective of this study was to examine prescription drug dispensations up to 15 years pre-MS symptom onset.
METHODS: Matched cohort study linking prescription, clinical and administrative data, 1996-2018.
RESULTS: Among 1243/6212 MS/non-MS persons, those with MS had higher dispensation rate ratios (RRs) pre-onset for systemic antibacterials up to 15 years (RR (range) = 1.15-1.30; q-values (range) = 0.11-0.31), airway drugs up to 8 years (RR (range) = 1.49-1.71; q-values (range) = 0.26-0.35), sex hormones (females only) up to 7 years (RR (range) = 1.19-1.46; q-values (range) = 0.26-0.39) and psychoanaleptics up to 6 years (RR (range) = 1.36-1.59; q-values (range) = 0.09-0.31), but lower beta-blockers (years 13-14 pre-onset, RRs = 0.10; q-values (range) = <0.00001-0.31). After multiple-comparison adjustment, beta-blockers remained significant.
CONCLUSION: Drug dispensations differed up to 15 years pre-MS onset and may reflect early disease.
OBJECTIVE: The objective of this study was to examine prescription drug dispensations up to 15 years pre-MS symptom onset.
METHODS: Matched cohort study linking prescription, clinical and administrative data, 1996-2018.
RESULTS: Among 1243/6212 MS/non-MS persons, those with MS had higher dispensation rate ratios (RRs) pre-onset for systemic antibacterials up to 15 years (RR (range) = 1.15-1.30; q-values (range) = 0.11-0.31), airway drugs up to 8 years (RR (range) = 1.49-1.71; q-values (range) = 0.26-0.35), sex hormones (females only) up to 7 years (RR (range) = 1.19-1.46; q-values (range) = 0.26-0.39) and psychoanaleptics up to 6 years (RR (range) = 1.36-1.59; q-values (range) = 0.09-0.31), but lower beta-blockers (years 13-14 pre-onset, RRs = 0.10; q-values (range) = <0.00001-0.31). After multiple-comparison adjustment, beta-blockers remained significant.
CONCLUSION: Drug dispensations differed up to 15 years pre-MS onset and may reflect early disease.