Molecular and cellular endocrinology · 2024
Melatonin improves nitric oxide bioavailability in isoproterenol induced myocardial injury.
СтатьяНазвание и аннотация: Перевод в очереди
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Santos Ramison, Turck Patrick, de Mello Palma Victor, Visioli Fernanda, Ortiz Vanessa Duarte, Proença Isabel Cristina Teixeira, Fernandes Tânia Regina G, Fernandes Elissa, Tasca Silvio, Carraro Cristina Campos, Belló-Klein Adriane, da Rosa Araujo Alex Sander, Khaper Neelam, de Castro Alexandre Luz
Аннотация
Isoproterenol administration is associated with cardiac inflammation and decreased NO availability. Melatonin has been reported to have cardioprotective effect. The aim of this study was to investigate the effect of melatonin on NO bioavailability and inflammation in myocardial injury induced by isoproterenol. Isoproterenol was administrated in male Wistar rats for 7 days to induce cardiac injury. The animals were divided into 3 groups: Control, Isoproterenol, Isoproterenol + Melatonin. Animals received melatonin for 7 days. Echocardiographic analysis was performed and the hearts were collected for molecular analysis. Animals that received isoproterenol demonstrated a reduction in left ventricle systolic and diastolic diameter, indicating the presence of concentric hypertrophy. Melatonin was able to attenuate this alteration. Melatonin also improved NO bioavailability and decreased NF-κβ, TNFα and IL-1β expression. In conclusion, melatonin exhibited a cardioprotective effect which was associated with improving NO bioavailability and decreasing the pro-inflammatory proteins.