Social Determinants of Health and Research Participation Among People Living With Mild Cognitive Impairment and Dementia.

IntroductionPeople most likely to be affected by Alzheimer's disease and related dementias (ADRD) are underrepresented in clinical research. Identifying and addressing factors which may influence their research participation is important to advance science and promote diversity. We examined the influence of social determinants of health (SDOH) on research participation among people living with ADRD.MethodsWe included those age 55 years and older living with ADRD, followed in our community practice in Rochester, Minnesota, who completed a questionnaire assessing SDOH and had at least one clinic visit between June 1, 2019 and June 1, 2020. Demographic and SDOH factors were examined by research participation.ResultsAmong 3273 people included, research participation was low overall (265/3273; 8.1%). People participating in research were more likely to be socially integrated and of higher educational attainment (p < 0.05).ConclusionPromoting social interaction is a potential area for focus to increase research participation in at risk populations.