Journal of assisted reproduction and genetics · 2025
Parental dietary patterns and assisted reproductive technology outcomes including embryo morphokinetics: rotterdam periconception cohort.
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Hojeij Batoul, Schoenmakers Sam, van Rossem Lenie, Willemsen Sten, Baart Esther, Rousian Melek, Steegers-Theunissen Régine P M
Аннотация
PURPOSE: This exploratory study investigated the associations between dietary patterns of subfertile couples and assisted reproductive technology (ART) outcomes, including preimplantation embryo morphokinetics.
METHODS: From the ongoing Rotterdam periconception cohort, we included 149 women and 126 men attending a fertility outpatient clinic for ART treatment. Dietary intake was assessed using a validated self-reported food frequency questionnaire with implausible dietary reporters excluded. We identified four dietary patterns in women and men separately. Embryo morphokinetics included the timing of each division from two to eight cell stage (t2 to t8) and to blastocyst formation, second and third cell cycle and synchrony, and the Known Implantation Data score on embryonic day 3 (KIDscore D3). ART outcomes included the fertilization rate, embryo yield, clinical pregnancy, and live birth.
RESULTS: Maternal adherence to the "Healthy" pattern was associated with shorter S2 (βadj -0.62 h, p = 0.024) and higher KIDscore D3 (ORadj 0.78, p = 0.011), while "Savory Snack and Alcohol" pattern was associated with slower t6 (βadj 0.869 h, p = 0.014), t7 (βadj 1.63 h, p < 0.001), and t8 (βadj 1.52 h, p = 0.01). Paternal adherence to the "Healthy" pattern was associated with faster t7 (βadj -1.10 h, p = 0.046), t8 (βadj -2.12 h, p = 0.001), and shorter S3 (βadj -1.72 h, p = 0.001), while "Potato-rich" pattern was associated with faster t2 (βadj -0.46 h, p = 0.012). Parental dietary patterns were not associated with ART outcomes.
CONCLUSIONS: This study showed small but consistent associations between parental diet and preimplantation embryo morphokinetics, with no overall effects on ART outcomes.
METHODS: From the ongoing Rotterdam periconception cohort, we included 149 women and 126 men attending a fertility outpatient clinic for ART treatment. Dietary intake was assessed using a validated self-reported food frequency questionnaire with implausible dietary reporters excluded. We identified four dietary patterns in women and men separately. Embryo morphokinetics included the timing of each division from two to eight cell stage (t2 to t8) and to blastocyst formation, second and third cell cycle and synchrony, and the Known Implantation Data score on embryonic day 3 (KIDscore D3). ART outcomes included the fertilization rate, embryo yield, clinical pregnancy, and live birth.
RESULTS: Maternal adherence to the "Healthy" pattern was associated with shorter S2 (βadj -0.62 h, p = 0.024) and higher KIDscore D3 (ORadj 0.78, p = 0.011), while "Savory Snack and Alcohol" pattern was associated with slower t6 (βadj 0.869 h, p = 0.014), t7 (βadj 1.63 h, p < 0.001), and t8 (βadj 1.52 h, p = 0.01). Paternal adherence to the "Healthy" pattern was associated with faster t7 (βadj -1.10 h, p = 0.046), t8 (βadj -2.12 h, p = 0.001), and shorter S3 (βadj -1.72 h, p = 0.001), while "Potato-rich" pattern was associated with faster t2 (βadj -0.46 h, p = 0.012). Parental dietary patterns were not associated with ART outcomes.
CONCLUSIONS: This study showed small but consistent associations between parental diet and preimplantation embryo morphokinetics, with no overall effects on ART outcomes.