Endocrine research · 2010
Selenium and hormone interactions in female patients with Hashimoto disease and healthy subjects.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Zagrodzki Paweł, Przybylik-Mazurek Elwira
Аннотация
OBJECTIVE: To examine the correlation structure of parameters expressing selenium status, sex hormones secretion and thyroid function in a group of patients with Hashimoto disease and healthy female subjects.
METHOD: Partial Least Square modeling was applied to parameters under study.
RESULTS: The correlations between relevant parameters were confirmed. Selenoenzyme glutathione peroxidase (GPX3) an progesterone played the most significant roles among factors contributing to thyroid stimulating hormone and free thyroxine regulation. Additionally, a correlation between GPX3 and estradiol was also observed which is in agreement with results reported by other authors. Patients with Hashimoto disease had lower glutathione peroxidase activities than healthy subjects.
CONCLUSION: The integrated multivariate approach applied to a new group of patients dissimilar to the previous one, was validated by statistical adequacy as well ass meaningful interpretation.
METHOD: Partial Least Square modeling was applied to parameters under study.
RESULTS: The correlations between relevant parameters were confirmed. Selenoenzyme glutathione peroxidase (GPX3) an progesterone played the most significant roles among factors contributing to thyroid stimulating hormone and free thyroxine regulation. Additionally, a correlation between GPX3 and estradiol was also observed which is in agreement with results reported by other authors. Patients with Hashimoto disease had lower glutathione peroxidase activities than healthy subjects.
CONCLUSION: The integrated multivariate approach applied to a new group of patients dissimilar to the previous one, was validated by statistical adequacy as well ass meaningful interpretation.