Integrative role of diet and gut microbiome dynamics for the interventive therapeutics of Spinocerebellar ataxia type 3: The current update.

Neurodegenerative disorders such as Alzheimer's and Parkinson's have captured researchers' attention regarding their connection to gut microbiota and dietary factors. Research has shown that changes in our regular dietary consumption can profoundly influence the composition of the gut microbiota, which possesses the capacity to influence brain functioning through a number of mechanisms, suggesting that dietary modifications may serve as promising therapeutic intervention for managing and potentially mitigating the progression of several neurodegenerative diseases. Spinocerebellar Ataxia Type 3 (SCA3), a neurodegenerative disorder stems from an unstable CAG trinucleotide repeat expansion within the ATXN3 gene's coding regions. This leads to the production of polyglutamine, contributing to a range of symptoms. However, the therapeutic potential of targeting gut microbiome alterations through dietary interventions for SCA3 has not been extensively investigated. This review is the first to systematically integrate existing evidence on how dietary interventions and gut microbiome dynamics may be leveraged for the therapeutic management of SCA3. Specifically, we explore how dietary components including fermented foods, probiotics, fiber-rich diets, herbal compounds and pharmacological agents, including dietary and natural HDAC inhibitors can influence gut microbiota and modulate neuroinflammation, oxidative stress, and protein aggregation, which are common hallmarks in neurodegenerative diseases. This paper elucidates the gut microbiota's ability to affect neurological health and its significance in the management of SCA3, hence facilitating future research aimed at treating SCA3 patients by dietary modifications that modify particular gut flora.