IJID regions · 2026
Distribution and antibiotic resistance profiles of uropathogens at Madan Bhandari Hospital, Nepal: Focus on multidrug and extensively drug-resistant strains.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Thapa Rahi Bikram, Karkee Prakash Chandra, Shrestha Sabin, Yadav Neha, Pokharel Rewati, Bhattarai Usha
Аннотация
OBJECTIVES: This study aimed to determine the distribution and antibiotic resistance patterns of uropathogens, emphasizing MDR and XDR strains, at a secondary care hospital to fill gaps in community-linked resistance data not captured by tertiary centers.
DESIGN OR METHODS: A total of 2734 urine cultures collected between June 2024 and April 2025 at Madan Bhandari Hospital were analyzed. Isolates were identified on Blood and MacConkey Agar, and antibiotic susceptibility testing was performed using the modified Kirby-Bauer disk diffusion method. MDR/XDR classification followed European Centre for Disease Prevention and Control/Centers for Disease Control and Prevention criteria.
RESULTS: Significant growth was found in 209 samples (7.64%), dominated by Escherichia coli (58.37%) and Klebsiella spp. (31.10%). High resistance rates were observed against ampicillin-sulbactam, cotrimoxazole, and ciprofloxacin. Overall, 22.96% of isolates were MDR and 7.65% XDR. Meropenem, doxycycline, and nitrofurantoin showed better activity, although resistance among Klebsiella spp. remained high.
CONCLUSION: The high prevalence of MDR/XDR uropathogens and resistance to first-line antibiotics underscores the importance of incorporating local surveillance data into treatment protocols. Conducting this study in a secondary hospital provides a clearer representation of community-linked resistance patterns, complementing tertiary hospital data and informing targeted antimicrobial stewardship strategies in Nepal.
DESIGN OR METHODS: A total of 2734 urine cultures collected between June 2024 and April 2025 at Madan Bhandari Hospital were analyzed. Isolates were identified on Blood and MacConkey Agar, and antibiotic susceptibility testing was performed using the modified Kirby-Bauer disk diffusion method. MDR/XDR classification followed European Centre for Disease Prevention and Control/Centers for Disease Control and Prevention criteria.
RESULTS: Significant growth was found in 209 samples (7.64%), dominated by Escherichia coli (58.37%) and Klebsiella spp. (31.10%). High resistance rates were observed against ampicillin-sulbactam, cotrimoxazole, and ciprofloxacin. Overall, 22.96% of isolates were MDR and 7.65% XDR. Meropenem, doxycycline, and nitrofurantoin showed better activity, although resistance among Klebsiella spp. remained high.
CONCLUSION: The high prevalence of MDR/XDR uropathogens and resistance to first-line antibiotics underscores the importance of incorporating local surveillance data into treatment protocols. Conducting this study in a secondary hospital provides a clearer representation of community-linked resistance patterns, complementing tertiary hospital data and informing targeted antimicrobial stewardship strategies in Nepal.