American journal of Alzheimer's disease and other dementias · 2015
Simple Neuropsychological Tests May Identify Participants in Whom Aspirin Use Is Associated With Lower Dementia Incidence: The Canadian Study of Health and Aging.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Oveisgharan Shahram, Hachinski Vladimir
Аннотация
BACKGROUND: We hypothesized that neuropsychological tests could help in identifying preclinical stages of vascular cognitive impairment, when aspirin use might be associated with lower dementia incidence.
METHODS: We used data of Canadian Study of Health and Aging (CSHA) which was a longitudinal study of Canadians older than 65 years and was done in 3 waves, 1991 to 1992 (CSHA-1), 1996 to 1997 (CSHA-2), and 2001 to 2002.
RESULTS: CSHA-1 participants with vascular dementia performed worse in copying pentagons and writing subtests of modified Mini-Mental State Examination test than participants with probable Alzheimer's disease. Salicylates use was associated with lower incident dementia among normal cognition CSHA-1 participants who had low scores in copying pentagons and writing subtests after controlling for age, sex, education, and vascular risk factors (odds ratio = 0.25, 95% confidence interval: 0.073-0.86, P = .028).
CONCLUSIONS: Two simple neuropsychological tests might help in identifying preclinical stages of vascular cognitive impairment, and salicylates use was associated with lower dementia incidence.
METHODS: We used data of Canadian Study of Health and Aging (CSHA) which was a longitudinal study of Canadians older than 65 years and was done in 3 waves, 1991 to 1992 (CSHA-1), 1996 to 1997 (CSHA-2), and 2001 to 2002.
RESULTS: CSHA-1 participants with vascular dementia performed worse in copying pentagons and writing subtests of modified Mini-Mental State Examination test than participants with probable Alzheimer's disease. Salicylates use was associated with lower incident dementia among normal cognition CSHA-1 participants who had low scores in copying pentagons and writing subtests after controlling for age, sex, education, and vascular risk factors (odds ratio = 0.25, 95% confidence interval: 0.073-0.86, P = .028).
CONCLUSIONS: Two simple neuropsychological tests might help in identifying preclinical stages of vascular cognitive impairment, and salicylates use was associated with lower dementia incidence.