BMC infectious diseases · 2026
A new wave of resurge for GII.17[P17] norovirus in multiple provinces of China in 2024.
СтатьяНазвание и аннотация: Перевод в очереди
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Yang Shuting, Gao Jian, Cao Lijiao, Zhang Hailong, Ren Lina, Miao Ziping, Zhang Qing, Kong Xiangyu, Mei Guoyong, Sun Lingli, Zhou Shuaifeng, Jin Miao
Аннотация
INTRODUCTION: Noroviruses is a major cause of outbreaks and sporadic acute gastroenteritis (AGE) across all age groups. Although the GII.4 norovirus has been the primary cause of most AGE outbreaks, Non-GII.4 norovirus has been reported globally.
AIM: We aimed to report an increase in GII.17 norovirus outbreaks of acute gastroenteritis in multiple provinces of China during the second half of 2024.
METHODS: Data and specimens from AGE outbreaks (January 2022-December 2024) were collected. Samples were tested via real-time RT-PCR; positive GII.17[P17] samples underwent sequencing and phylogenetic analysis.
RESULTS: Among 1,579 norovirus outbreaks, 1,225 were genotyped. The first halves of 2022-2024 saw co-circulation of genotypes GII.3[P12], GII.4 Sydney, GII.17[P17], and GII.7[P7]. GII.4 Sydney dominated the second halves of 2022 (46.15%) and 2023 (51.63%). Strikingly, in the second half of 2024, GII.17[P17] became predominant, causing 75.28% of outbreaks. This shift was driven by a novel GII.17 variant (Romania-2021 like, subcluster C2), first detected in February 2024, which replaced the previous Kawasaki 308-like variant. The novel variant predominantly affected the 6-18 years age group (54.97%) and elementary schools (34.33%). Relative to Cluster D, this novel variant harbors five amino acid mutations in antigenic epitopes, one mutation in the histo-blood group antigen (HBGA) binding site, and two deletions.
CONCLUSIONS: A novel GII.17 variant has overtaken GII.4 as the predominant norovirus strain in China since late 2024, underscoring the need for continued molecular surveillance.
AIM: We aimed to report an increase in GII.17 norovirus outbreaks of acute gastroenteritis in multiple provinces of China during the second half of 2024.
METHODS: Data and specimens from AGE outbreaks (January 2022-December 2024) were collected. Samples were tested via real-time RT-PCR; positive GII.17[P17] samples underwent sequencing and phylogenetic analysis.
RESULTS: Among 1,579 norovirus outbreaks, 1,225 were genotyped. The first halves of 2022-2024 saw co-circulation of genotypes GII.3[P12], GII.4 Sydney, GII.17[P17], and GII.7[P7]. GII.4 Sydney dominated the second halves of 2022 (46.15%) and 2023 (51.63%). Strikingly, in the second half of 2024, GII.17[P17] became predominant, causing 75.28% of outbreaks. This shift was driven by a novel GII.17 variant (Romania-2021 like, subcluster C2), first detected in February 2024, which replaced the previous Kawasaki 308-like variant. The novel variant predominantly affected the 6-18 years age group (54.97%) and elementary schools (34.33%). Relative to Cluster D, this novel variant harbors five amino acid mutations in antigenic epitopes, one mutation in the histo-blood group antigen (HBGA) binding site, and two deletions.
CONCLUSIONS: A novel GII.17 variant has overtaken GII.4 as the predominant norovirus strain in China since late 2024, underscoring the need for continued molecular surveillance.