Zeitschrift fur Geburtshilfe und Neonatologie · 2007
[Secretion and regulation of cytokines during pregnancy and gestosis].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Strittmatter H-J, Blecken S R
Аннотация
OBJECTIVE: Pregnancy-induced hypertension is still a common cause for fetal morbidity and mortality besides causing life-threatening diseases for the mother. The aethiology of this disease is still unclear. Some research support the theory of an immunological genesis.
PATIENTS AND METHODS: 32 patients were treated for gestosis or HELLP-Syndrome in our clinic. A number of data, blood samples as well as the immunological status (IL-6, Interferon-gamma. TNF-alpha und TNF-alpha-receptores p 55/p 75) of every patient were taken into consideration and compared to the results of 44 pregnant women in good health.
RESULTS: Predisposing factors seem to have an crucial impact on the development of PIH. Under stimulation of peripheral blood monocytes the immunological results and the measurement of cytokines showed a significantly higher concentration of TNF-alpha compared to the results of the control group. The tendency of an increase of TNF-alpha-receptors p 75 was observed however it proved to have no statistical relevant when comparing the results of both groups.
DISCUSSION: An new approach to examine the aethiology of pregnancy-induced hypertensive diseases consists in measuring immunotransmitters such as interferon, Interleukin and the tumor necrosis factor. The increased concentration of TNF-alpha and TNF-alpha-receptor shows the involvement of the cytokines thus supporting the hypothesis of an immunological genesis.
PATIENTS AND METHODS: 32 patients were treated for gestosis or HELLP-Syndrome in our clinic. A number of data, blood samples as well as the immunological status (IL-6, Interferon-gamma. TNF-alpha und TNF-alpha-receptores p 55/p 75) of every patient were taken into consideration and compared to the results of 44 pregnant women in good health.
RESULTS: Predisposing factors seem to have an crucial impact on the development of PIH. Under stimulation of peripheral blood monocytes the immunological results and the measurement of cytokines showed a significantly higher concentration of TNF-alpha compared to the results of the control group. The tendency of an increase of TNF-alpha-receptors p 75 was observed however it proved to have no statistical relevant when comparing the results of both groups.
DISCUSSION: An new approach to examine the aethiology of pregnancy-induced hypertensive diseases consists in measuring immunotransmitters such as interferon, Interleukin and the tumor necrosis factor. The increased concentration of TNF-alpha and TNF-alpha-receptor shows the involvement of the cytokines thus supporting the hypothesis of an immunological genesis.