Molecules (Basel, Switzerland) · 2012
Phenolic enriched extract of Baccharis trimera presents anti-inflammatory and antioxidant activities.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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de Oliveira Cristiane B, Comunello Lucimara N, Lunardelli Adroaldo, Amaral Robson H, Pires Melissa G S, da Silva Gabriela Lucas, Manfredini Vanusa, Vargas Carmen Regla, Gnoatto Simone C B, de Oliveira Jarbas R, Gosmann Grace
Аннотация
Baccharis trimera is a plant popularly used as a tea and to treat gastrointestinal diseases and inflammatory processes as well. The total phenolic content was determined and the antioxidant and anti-inflammatory activities of six extracts (dichloromethane, ethyl acetate, butanol, aqueous, saponin and phenolic) from B. trimera were evaluated. Using carrageenan-induced pleurisy as a model of acute inflammation, the phenolic extract at 15 mg/kg decreased significantly the analyzed parameters when compared to the carrageenan group ( p < 0.05), thus showing potential anti-inflammatory activity. The total phenolic content and antioxidant activity were evaluated by the Folin-Ciocalteau and DPPH methods, respectively. Phenolic and ethyl acetate extracts presented higher antioxidant activity ( p < 0.05) than ascorbic acid. The phenolic extract also showed the highest antioxidant potential in relation to the other extracts, thus suggesting that the antioxidant and anti-inflammatory activities were due to the presence of phenolic compounds.