Navigating Acute and Late-Onset Toxicities After Chimeric Antigen Receptor T-Cell Therapy: A Patient-Centered Nursing Approach.

BACKGROUND

Patients with cancer undergoing advanced therapies, such as chimeric antigen receptor (CAR) T-cell therapy, experience complex treatment-related toxicities that require timely recognition and management. Nurses educate, monitor, and intervene to optimize outcomes and support quality survivorship care for patients.

OBJECTIVES

This article highlights evidence-based interventions for managing treatment-related complications and outlines strategies to support safe, high-quality care throughout CAR T-cell treatment.

METHODS

The author conducted a literature review using PubMed®, CINAHL®, and key oncology nursing guidelines to examine relevant studies, guidance, and expert consensus statements to synthesize best practices for nursing assessment and management of immune-based therapy complications.

FINDINGS: Clinicians ensure safe and effective care through early toxicity recognition, standardized assessment protocols, and multidisciplinary coordination. Evidence-based interventions, as well as psychological support, contribute to improved patient outcomes. Ongoing education and professional development remain essential.