Clinical neurology and neurosurgery · 2026
Lymphopenia predicts infectious complications after alemtuzumab therapy in multiple sclerosis: Real-world experience from a Brazilian cohort.
СтатьяНазвание и аннотация: Перевод в очереди
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Tejo Alexandre Mestre, Silva Guilherme Diogo, de Holanda Arthur Cesário, Adoni Tarso, Pereira Samira Luísa Apóstolos, Callegaro Dagoberto, Tonacio Adriana Coracini
Аннотация
OBJECTIVE: Alemtuzumab, a humanized monoclonal anti-CD52 antibody, is an effective therapy for relapsing multiple sclerosis (MS) but is associated with an increased risk of infections. Real-world safety data from tropical and middle-income settings remain limited. We aimed to evaluate infectious complications after alemtuzumab therapy and identify clinical predictors of infection.
METHODS: We performed a retrospective analysis of a prospectively maintained database of all MS patients receiving a first course of alemtuzumab at the largest public hospital in Brazil between February 2023 and August 2024. Clinical and laboratory data were collected through monthly follow-up.
RESULTS: Forty-four patients received alemtuzumab, and 29 (65.9%) developed at least one infectious episode, totaling 47 events. Most infections were mild, predominantly upper respiratory (33.9%) and urinary tract infections (25.5%). Three hospitalizations occurred, with no deaths. Infection risk increased during periods of lower lymphocyte counts. In a generalized estimating equation model adjusted for follow-up month, lymphocyte counts below 500 cells/μL were associated with higher odds of infection during the corresponding monthly interval (OR 3.69; 95% CI 1.70-7.98; p = 0.0009). Leukocyte and neutrophil counts were not associated with infection occurrence.
CONCLUSION: In this real-world cohort, infectious events after alemtuzumab were common but mostly mild. Lymphocyte counts below 500 cells/μL identified periods of increased infection risk, supporting intensified clinical and laboratory monitoring during immune depletion.
METHODS: We performed a retrospective analysis of a prospectively maintained database of all MS patients receiving a first course of alemtuzumab at the largest public hospital in Brazil between February 2023 and August 2024. Clinical and laboratory data were collected through monthly follow-up.
RESULTS: Forty-four patients received alemtuzumab, and 29 (65.9%) developed at least one infectious episode, totaling 47 events. Most infections were mild, predominantly upper respiratory (33.9%) and urinary tract infections (25.5%). Three hospitalizations occurred, with no deaths. Infection risk increased during periods of lower lymphocyte counts. In a generalized estimating equation model adjusted for follow-up month, lymphocyte counts below 500 cells/μL were associated with higher odds of infection during the corresponding monthly interval (OR 3.69; 95% CI 1.70-7.98; p = 0.0009). Leukocyte and neutrophil counts were not associated with infection occurrence.
CONCLUSION: In this real-world cohort, infectious events after alemtuzumab were common but mostly mild. Lymphocyte counts below 500 cells/μL identified periods of increased infection risk, supporting intensified clinical and laboratory monitoring during immune depletion.