European journal of dermatology : EJD · 2019
Congenital nevi with hypomelanosis and fine scales.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Natsuga Ken, Oiso Naoki, Kurokawa Ichiro, Tsubura Airo, Nakamura Hideki, Maya Yuka, Nishie Wataru, Kawada Akira, Shimizu Hiroshi
Аннотация
BACKGROUND: Nevus is a hamartoma or malformation of one or more skin components, resulting in aberrant differentiation of the cell lineage(s) mostly during developmental stages. Although multiple lineages may be involved in a nevus, the combination of melanocyte and keratinocyte abnormalities has been rarely discussed.
OBJECTIVES: To present two cases of congenital nevi with hypomelanosis and superficial fine scales.
MATERIALS & METHODS: Skin specimens of the patients were analysed by immunohistochemistry and electron microscopy.
RESULTS: Morphological and immunohistochemical studies indicated aberrant epidermal differentiation in the lesional skin specimens. Electron microscopy showed defective melanosome maturation in the melanocytes of the nevi samples.
CONCLUSION: These results demonstrate that both epidermal and melanocytic lineages can concomitantly contribute to the formation of a nevus lesion.
OBJECTIVES: To present two cases of congenital nevi with hypomelanosis and superficial fine scales.
MATERIALS & METHODS: Skin specimens of the patients were analysed by immunohistochemistry and electron microscopy.
RESULTS: Morphological and immunohistochemical studies indicated aberrant epidermal differentiation in the lesional skin specimens. Electron microscopy showed defective melanosome maturation in the melanocytes of the nevi samples.
CONCLUSION: These results demonstrate that both epidermal and melanocytic lineages can concomitantly contribute to the formation of a nevus lesion.