Association of multiple inflammatory index markers with overactive bladder syndrome: A cross-sectional study results from the NHANES 2005 to 2018.

The Systemic Inflammatory Response Index (SIRI), neutrophil/lymphocyte ratio, Aggregate Inflammatory Syndrome Index, monocyte/lymphocyte ratio, platelet/lymphocyte ratio, and Systemic Inflammatory Index are readily accessible inflammatory biomarkers. The pathogenesis of overactive bladder (OAB) is considered related to the inflammatory response. This study aims to explore the relationships between these biomarkers and OAB and to assess their potential as predictors of disease onset. This study is a retrospective cross-sectional analysis utilizing data from the National Health and Nutrition Examination Survey from 2005 to 2018. Given the preexisting nature of the National Health and Nutrition Examination Survey data collection, this study retrospectively evaluates the association between systemic inflammatory markers and OAB based on previously recorded clinical and demographic variables. A total of 32,115 participants were analyzed. Our findings demonstrated a significant association between systemic inflammatory markers and OAB. Among the inflammatory indices, SIRI (odds ratio [OR] = 1.184, 95% confidence interval [95% CI]: 1.150-1.220, P < .001), neutrophil/lymphocyte ratio (OR = 1.116, 95% CI: 1.091-1.141, P < .001), and monocyte/lymphocyte ratio (OR = 2.632, 95% CI: 2.116-3.275, P < .001) exhibited the strongest association with OAB. Receiver operating characteristic analysis indicated that SIRI had the highest predictive value (area under the curve = 0.549, 95% CI: 0.541-0.557, P < .05). These findings suggest that systemic inflammation may play a crucial role in OAB pathogenesis. Levels of the biomarkers were significantly correlated with the incidence of OAB. In the U.S., individuals with elevated levels of these markers exhibited a higher prevalence of OAB.