Increased adenosine deaminase in hydatidiform mole.

BACKGROUND

The aim of the current study was to investigate levels of adenosine deaminase in plasma of patients with hydatidiform mole.

METHODS

Plasma adenosine deaminase levels were determined in 17 women with normal pregnant course, in 17 women with hydatidiform mole, and in 17 non-pregnant healthy volunteers.

RESULTS

Mean adenosine deaminase activity in the hydatidiform mole group was 121.5+/-24.8 U/L, significantly higher than in the pregnant control (7.8+/-6.5 U/L; p<0.0001) and non-pregnant control groups (6.4+/-7.4 U/L; p<0.0001). A cutoff level of 40.5 U/L was found, with both sensitivity and specificity of 100%.

CONCLUSIONS

Adenosine deaminase may play a role in the development of hydatidiform mole.