IJU case reports · 2026
Successful Treatment of Primary Mediastinal Seminoma With Radiotherapy Following Chemotherapy Under a Bloodless Treatment Policy Based on Patient's Religious Sentiments.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Fujii Eisuke, Yamamoto Yoshiyuki, Takezawa Kentaro, Hatano Koji, Kakuta Yoichi, Kawashima Atsunari, Nonomura Norio, Kato Taigo
Аннотация
INTRODUCTION: Primary mediastinal seminoma is rare with a favorable prognosis when appropriately treated, and surgical resection after chemotherapy is the standard treatment. However, refusal of blood transfusion for religious reasons can limit curative surgical management.
CASE PRESENTATION: A 47-year-old Jehovah's Witness man was found to have a 10.8-cm anterior mediastinal tumor. Biopsy confirmed seminoma. As the patient refused transfusion, definitive chemotherapy followed by radiotherapy was selected. Three cycles of chemotherapy (etoposide, ifosfamide, and cisplatin) resulted in 44% tumor reduction and partial response. Intensity-modulated radiotherapy of the residual tumor (36 Gy in 20 fractions) achieved complete response, maintained for 11 months without recurrence or late toxicity.
CONCLUSION: Sequential chemotherapy followed by consolidative radiotherapy appeared to be a safe and effective option for primary mediastinal germ cell tumor in the short term when surgical resection was not feasible for religious reasons.
CASE PRESENTATION: A 47-year-old Jehovah's Witness man was found to have a 10.8-cm anterior mediastinal tumor. Biopsy confirmed seminoma. As the patient refused transfusion, definitive chemotherapy followed by radiotherapy was selected. Three cycles of chemotherapy (etoposide, ifosfamide, and cisplatin) resulted in 44% tumor reduction and partial response. Intensity-modulated radiotherapy of the residual tumor (36 Gy in 20 fractions) achieved complete response, maintained for 11 months without recurrence or late toxicity.
CONCLUSION: Sequential chemotherapy followed by consolidative radiotherapy appeared to be a safe and effective option for primary mediastinal germ cell tumor in the short term when surgical resection was not feasible for religious reasons.