Ophthalmology. Glaucoma · 2026
Long-Term Risk of Mortality and Systemic Morbidity in Neovascular Glaucoma: A Multicenter Retrospective Cohort Study.
СтатьяМногоцентровое исследованиеНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Margolis Ryan, Vasu Pranav, Dorairaj Syril K
Аннотация
PURPOSE: To evaluate long-term systemic risks associated with neovascular glaucoma (NVG) using a large observational data set from the TriNetX Research Network.
DESIGN: Retrospective cohort study.
SUBJECTS: Adults >40 years old with central retinal vein occlusion (CRVO) or proliferative diabetic retinopathy (PDR) were compared based on whether they did or did not subsequently develop NVG.
METHODS: Patients were propensity score matched 1:1 based on demographics and comorbidities. Outcomes were assessed at 1, 5, and 10 years using hazard ratios (HRs) with 95% confidence intervals (CIs). Subgroup analysis compared outcomes in PDR + NVG versus CRVO + NVG. Neovascular glaucoma patients were also compared with a cataract control cohort.
MAIN OUTCOME MEASURES: Risk of all-cause mortality, stroke, myocardial infarction (MI), end-stage renal disease (ESRD), and deep vein thrombosis (DVT).
RESULTS: Patients with PDR who developed NVG had a higher long-term risk than PDR alone, including elevated 10-year mortality (HR, 1.34; 95% CI, 1.14-1.57) and ESRD (HR, 1.43; 95% CI, 1.23-1.67). Among patients with CRVO, the development of NVG increased 10-year mortality (HR, 1.61; 95% CI, 1.17-2.20) and stroke (HR, 1.86; 95% CI, 1.19-2.90), whereas MI and ESRD were not significantly different. DVT risk was not significantly different. Subgroup comparison showed that PDR + NVG had a higher 10-year risk of mortality (HR, 1.56; 95% CI, 1.17-2.07), MI (HR, 1.94; 95% CI, 1.13-3.32), and ESRD (HR, 4.04; 95% CI, 2.43-6.73) compared with CRVO + NVG. Compared with cataract control at 10 years, NVG was associated with higher risks of mortality (HR, 2.66; 95% CI, 2.40-2.94), stroke (HR, 2.17; 95% CI, 1.85-2.54), MI (HR, 1.89; 95% CI, 1.60-2.23), and ESRD (HR, 3.34; 95% CI, 2.89-3.88).
CONCLUSIONS: Neovascular glaucoma itself appears to add systemic risk beyond underlying PDR or CRVO, suggesting that the onset of NVG may represent a critical breakpoint in the spectrum of systemic vascular disease. Our results highlight the importance of coordinated ophthalmic and multispecialty care at the time of diagnosis.
FINANCIAL DISCLOSURE(S): The authors have no proprietary or commercial interest in any materials discussed in this article.
DESIGN: Retrospective cohort study.
SUBJECTS: Adults >40 years old with central retinal vein occlusion (CRVO) or proliferative diabetic retinopathy (PDR) were compared based on whether they did or did not subsequently develop NVG.
METHODS: Patients were propensity score matched 1:1 based on demographics and comorbidities. Outcomes were assessed at 1, 5, and 10 years using hazard ratios (HRs) with 95% confidence intervals (CIs). Subgroup analysis compared outcomes in PDR + NVG versus CRVO + NVG. Neovascular glaucoma patients were also compared with a cataract control cohort.
MAIN OUTCOME MEASURES: Risk of all-cause mortality, stroke, myocardial infarction (MI), end-stage renal disease (ESRD), and deep vein thrombosis (DVT).
RESULTS: Patients with PDR who developed NVG had a higher long-term risk than PDR alone, including elevated 10-year mortality (HR, 1.34; 95% CI, 1.14-1.57) and ESRD (HR, 1.43; 95% CI, 1.23-1.67). Among patients with CRVO, the development of NVG increased 10-year mortality (HR, 1.61; 95% CI, 1.17-2.20) and stroke (HR, 1.86; 95% CI, 1.19-2.90), whereas MI and ESRD were not significantly different. DVT risk was not significantly different. Subgroup comparison showed that PDR + NVG had a higher 10-year risk of mortality (HR, 1.56; 95% CI, 1.17-2.07), MI (HR, 1.94; 95% CI, 1.13-3.32), and ESRD (HR, 4.04; 95% CI, 2.43-6.73) compared with CRVO + NVG. Compared with cataract control at 10 years, NVG was associated with higher risks of mortality (HR, 2.66; 95% CI, 2.40-2.94), stroke (HR, 2.17; 95% CI, 1.85-2.54), MI (HR, 1.89; 95% CI, 1.60-2.23), and ESRD (HR, 3.34; 95% CI, 2.89-3.88).
CONCLUSIONS: Neovascular glaucoma itself appears to add systemic risk beyond underlying PDR or CRVO, suggesting that the onset of NVG may represent a critical breakpoint in the spectrum of systemic vascular disease. Our results highlight the importance of coordinated ophthalmic and multispecialty care at the time of diagnosis.
FINANCIAL DISCLOSURE(S): The authors have no proprietary or commercial interest in any materials discussed in this article.