Frontiers in psychology · 2026
Independent associations of fatigue with cognitive function and quality of life in multiple sclerosis: a cross-sectional study.
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Formica Caterina, Bonanno Lilla, Culicetto Laura, Lombardo Facciale Antonino, Sessa Edoardo, Rifici Carmela, Quartarone Angelo, Marino Silvia, Calabrò Rocco Salvatore, Latella Desirèe
Аннотация
INTRODUCTION: The aim of the study is to investigate the association between fatigue, cognitive impairment, and overall QoL in individuals with Multiple Sclerosis (MS).
METHODS: Fifty-one patients with MS with a confirmed diagnosis of relapsing-remitting multiple sclerosis (RRMS), according to established diagnostic criteria were enrolled. Data were collected at a single time point to examine associations between fatigue, cognitive functioning, neurological disability, and health-related quality of life (QoL). All participants were submitted to a standardized neurological examination, Fatigue symptoms were assessed using the Fatigue Severity Scale (FSS), Modified Fatigue Impact Scale (MFIS) and Fatigue Scale for Motor and Cognitive Functions (FSMC). Cognitive profiles were evaluated with the Brief Repeatable Battery of Neuropsychological Tests (BRB-N), overall Quality of Life with the Multiple Sclerosis Quality Ff Life (MSQOL-54) and the Expanded Disability Status Scale (EDSS) to evaluate the disability status.
RESULTS: Our findings indicate a significative correlation between general FATIGUE and multiple QoL outcomes. Specifically, fatigue was strongly correlated with Health Perception (ρ = 0.63, p < 0.001), Overall Quality of Life (ρ = 0.65, p < 0.001), Role Physical Limitation (ρ = 0.43, p = 0.002), and Role Emotional Limitation (ρ = 0.37, p = 0.007), and is also related to specific aspects of cognitive functioning as well as Symbol Digit Modalities Test (SDMT) (r = -0.38, p = 0.006) and Selective Reminding Test - Delayed (r = -0.36, p = 0.01).
DISCUSSION: These results contribute to a more comprehensive understanding of disease burden in MS, highlighting fatigue as a key factor that interacts with multiple dimensions of patient functioning.
CLINICAL TRIAL REGISTRATION: Identifier (NCT05783999).
METHODS: Fifty-one patients with MS with a confirmed diagnosis of relapsing-remitting multiple sclerosis (RRMS), according to established diagnostic criteria were enrolled. Data were collected at a single time point to examine associations between fatigue, cognitive functioning, neurological disability, and health-related quality of life (QoL). All participants were submitted to a standardized neurological examination, Fatigue symptoms were assessed using the Fatigue Severity Scale (FSS), Modified Fatigue Impact Scale (MFIS) and Fatigue Scale for Motor and Cognitive Functions (FSMC). Cognitive profiles were evaluated with the Brief Repeatable Battery of Neuropsychological Tests (BRB-N), overall Quality of Life with the Multiple Sclerosis Quality Ff Life (MSQOL-54) and the Expanded Disability Status Scale (EDSS) to evaluate the disability status.
RESULTS: Our findings indicate a significative correlation between general FATIGUE and multiple QoL outcomes. Specifically, fatigue was strongly correlated with Health Perception (ρ = 0.63, p < 0.001), Overall Quality of Life (ρ = 0.65, p < 0.001), Role Physical Limitation (ρ = 0.43, p = 0.002), and Role Emotional Limitation (ρ = 0.37, p = 0.007), and is also related to specific aspects of cognitive functioning as well as Symbol Digit Modalities Test (SDMT) (r = -0.38, p = 0.006) and Selective Reminding Test - Delayed (r = -0.36, p = 0.01).
DISCUSSION: These results contribute to a more comprehensive understanding of disease burden in MS, highlighting fatigue as a key factor that interacts with multiple dimensions of patient functioning.
CLINICAL TRIAL REGISTRATION: Identifier (NCT05783999).