Natural product research · 2026
A new fatty acid derivative derived from the deep-sea fungus Aspergillus sp. SCSIO41324.
СтатьяНазвание и аннотация: Перевод в очереди
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История · было → стало
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Chen Yu-Shi, Song Ying-Ying, Deng Sheng-Yi, Xiao Xin-Kai, Pang Xiao-Yan, Zhang Wei-Jia, Liu Yong-Hong, Cui Hong-Hua, Wang Jun-Feng
Аннотация
One new fatty acid derivative (3Z,5E)-8-(hydroxymethyl)-2-(3-methoxy-2-methyl-3-oxopropyl)-4,6,10,12-tetramethyltetradeca-2,4-dienoic acid (1) and fifteen known compounds 2-16 were isolated from the Aspergillus sp. SCSIO41324 derived fungus from the deep sea. Comprehensive NMR experiments and high-resolution electrospray ionisation mass spectrometry data were combined to elucidate the structure of this new metabolite. All obtained constituents were evaluated for their bioactivities. Compound 2 showed mild neuraminidase inhibition, with an IC50 value of 74.44 μM. Subsequent molecular docking was performed to explore its binding modes with the enzyme.