Opioid withdrawal-induced hypomania: a case series.

The aim of this study was to report hypomanic symptoms after opioid withdrawal. In this case series, nine opioid-dependent patients with hypomanic profile on opioid withdrawal were selected from outpatients in a private psychiatric clinic. Opium dependency was diagnosed according to Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition). Substance history, clinical features, temperament, and family history were retrospectively probed. Patients displayed pure or mixed hypomanic symptoms on opioid withdrawal. In nearly all subjects, the symptoms continued until individuals started taking the opioid again. Features of hyperthymic temperament and family history of bipolarity were traced in most of the individuals.