Pediatric pulmonology · 2026
Correlation of Transcutaneous pCO2 and Capillary pCO2 in Newborn Patients Depending on Gestational Age: A Secondary Data Analysis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Olivier Lena, Lauterbach Oprea Camelia, Stollenwerk André, Pfannschmidt Valerie, Orlikowsky Thorsten, Schoberer Mark
Аннотация
INTRODUCTION: Transcutaneous monitoring of CO2 partial pressure (tcpCO2) provides continuous information about the CO2 partial pressure in the blood (pCO2). However, the deviation of tcpCO2 from pCO2 is variable. Our aim was to assess whether this deviation depends on gestational age in the first postnatal week.
METHODS: Single-center secondary data cohort study at a Tertiary Care NICU. 116 neonates undergoing tcpCO2 monitoring were included. A linear mixed-effects model was used to analyze the difference between tcpCO2 and capillary pCO2 (ΔpCO2) in the first postnatal week.
RESULTS: 926 simultaneous measurements were included. The evaluation of the linear mixed-effects model revealed a significant effect of gestational age on ΔpCO2. Median [interquartile 1; interquartile 3] ΔpCO2 was significantly higher for extremely preterm infants (< 28 weeks) with 7.6 [2.4; 13.9] mmHg compared to 3.1 [-1.0; 6.4] mmHg for very preterm (28-31 + 6 weeks), 0.6 [-4.6; 4.7] mmHg for late preterm (32-36 + 6 weeks) and -0.5 [-4.8; 4.7] mmHg for term infants (≥ 37 weeks). There were no significant differences in ΔpCO2 between patients born at 23 to 25 compared to 26 and 27 completed weeks of gestation. In multivariable analysis, gestational age, early-onset bacterial infection and capillary pCO2 were independently associated with ΔpCO2, whereas birth weight was not.
CONCLUSIONS: The gestational age has a significant directed effect on the accuracy of transcutaneous CO2 monitoring in preterm neonates and can-together with other known influence factors-be used to improve the non-invasive pCO2 estimation.
METHODS: Single-center secondary data cohort study at a Tertiary Care NICU. 116 neonates undergoing tcpCO2 monitoring were included. A linear mixed-effects model was used to analyze the difference between tcpCO2 and capillary pCO2 (ΔpCO2) in the first postnatal week.
RESULTS: 926 simultaneous measurements were included. The evaluation of the linear mixed-effects model revealed a significant effect of gestational age on ΔpCO2. Median [interquartile 1; interquartile 3] ΔpCO2 was significantly higher for extremely preterm infants (< 28 weeks) with 7.6 [2.4; 13.9] mmHg compared to 3.1 [-1.0; 6.4] mmHg for very preterm (28-31 + 6 weeks), 0.6 [-4.6; 4.7] mmHg for late preterm (32-36 + 6 weeks) and -0.5 [-4.8; 4.7] mmHg for term infants (≥ 37 weeks). There were no significant differences in ΔpCO2 between patients born at 23 to 25 compared to 26 and 27 completed weeks of gestation. In multivariable analysis, gestational age, early-onset bacterial infection and capillary pCO2 were independently associated with ΔpCO2, whereas birth weight was not.
CONCLUSIONS: The gestational age has a significant directed effect on the accuracy of transcutaneous CO2 monitoring in preterm neonates and can-together with other known influence factors-be used to improve the non-invasive pCO2 estimation.