Anaphylaxis after ingestion of millet seeds.

We report the case of a patient with anaphylaxis after ingestion of millet seeds, a previously unreported allergen. Skin testing with freshly prepared millet seed extract produced positive intradermal responses at a concentration of 100 pg/ml. The reaction was mediated by IgE antibodies to millet, as demonstrated by elevated specific IgE antibody levels by radioallergosorbent test (RAST) and by significant in vitro histamine release from leukocytes incubated with millet seed extract.