Two new cassane derivatives from the seeds of Hultholia mimosoides.

Two previously undescribed cassane diterpenoids, caesmimo C3 (1) and caesmimo C8 (2), were isolated from the seeds of Hultholia mimosoides. Their structures were established by comprehensive spectroscopic analysis, and the absolute configurations were assigned from the electronic circular dichroism spectrum. Bioactively, compounds 1 and 2 exhibited significant cytotoxicity, inhibiting the cell viability of NRK-52E cells at a concentration of 50 μM.