Frontiers in pediatrics · 2026
Early-onset preeclampsia exposure and hospital outcomes of very preterm infants: a retrospective analysis of feeding intolerance and hospital morbidities.
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Li Xinyue, Zhang Hui, Dong Wenxin, Han Tongyan
Аннотация
BACKGROUND: Maternal early-onset preeclampsia (EOPE) may affect gastrointestinal function in very preterm infants, but its independent association with feeding intolerance (FI) and in-hospital morbidities remains unclear.
METHODS: This retrospective 1:1 gestational age-matched cohort study included 87 very preterm infants (<32 weeks) exposed to EOPE and 87 controls born to normotensive mothers. The primary outcome was FI. The secondary outcomes included bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), late-onset sepsis (LOS), retinopathy of prematurity (ROP), parenteral nutrition-associated cholestasis (PNAC), extrauterine growth restriction (EUGR), and mortality.
RESULTS: EOPE-exposed infants exhibited a significantly higher incidence of FI (77.0% vs. 41.4%, P < 0.001) and a prolonged time to full enteral feeding (13.0 vs. 9.5 days, P = 0.017). Multivariable logistic regression identified EOPE as an independent factor associated with FI (OR=2.290, 95% CI: 1.061-4.944, P = 0.035). Lower birth weight was also independently associated with an increased risk of FI.
CONCLUSION: Maternal EOPE may be associated with an increased risk of FI in very preterm infants, underscoring the necessity for targeted feeding monitoring and nutritional support in this population.
METHODS: This retrospective 1:1 gestational age-matched cohort study included 87 very preterm infants (<32 weeks) exposed to EOPE and 87 controls born to normotensive mothers. The primary outcome was FI. The secondary outcomes included bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), late-onset sepsis (LOS), retinopathy of prematurity (ROP), parenteral nutrition-associated cholestasis (PNAC), extrauterine growth restriction (EUGR), and mortality.
RESULTS: EOPE-exposed infants exhibited a significantly higher incidence of FI (77.0% vs. 41.4%, P < 0.001) and a prolonged time to full enteral feeding (13.0 vs. 9.5 days, P = 0.017). Multivariable logistic regression identified EOPE as an independent factor associated with FI (OR=2.290, 95% CI: 1.061-4.944, P = 0.035). Lower birth weight was also independently associated with an increased risk of FI.
CONCLUSION: Maternal EOPE may be associated with an increased risk of FI in very preterm infants, underscoring the necessity for targeted feeding monitoring and nutritional support in this population.