International journal of environmental research and public health · 2022
Development of a Cyclic Voltammetry-Based Method for the Detection of Antigens and Antibodies as a Novel Strategy for Syphilis Diagnosis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Barros Gabriel M C, Carvalho Dionísio D A, Cruz Agnaldo S, Morais Ellen K L, Sales-Moioli Ana Isabela L, Pinto Talita K B, Almeida Melise C D, Sanchez-Gendriz Ignacio, Fernandes Felipe, Barbalho Ingridy M P, Santos João P Q, Henriques Jorge M O, Teixeira César A D, Gil Paulo, Gama Lúcio, Miranda Angélica E, Coutinho Karilany D, Galvão-Lima Leonardo J, Valentim Ricardo A M
Аннотация
The improvement of laboratory diagnosis is a critical step for the reduction of syphilis cases around the world. In this paper, we present the development of an impedance-based method for detecting T. pallidum antigens and antibodies as an auxiliary tool for syphilis laboratory diagnosis. We evaluate the voltammetric signal obtained after incubation in carbon or gold nanoparticle-modified carbon electrodes in the presence or absence of Poly-L-Lysine. Our results indicate that the signal obtained from the electrodes was sufficient to distinguish between infected and non-infected samples immediately (T0') or 15 min (T15') after incubation, indicating its potential use as a point-of-care method as a screening strategy.