Investigating Hippocampal Alterations Following Traumatic Brain Injury.

Hippocampal atrophy in moderate to severe traumatic brain injury (msTBI) may indicate neurodegenerative progression. This study compared hippocampal parenchyma fraction (HPF) between thirty two patients with msTBI at 3 months post-injury and thirty five healthy controls (HC). T1-weighed images were used to calculate HPF using kaiba software. A t-test revealed that HPF was significantly lower in msTBI patients (p < 0.001). A general linear model, adjusted for age and gender, also showed a significant association between HPF and group differences (p < 0.001).