Lewis Base-Catalyzed DYKAT of Racemic Chlorosilanes En Route to Si-Stereogenic Silazanes.

A dynamic kinetic asymmetric transformation (DYKAT) of racemic chlorosilanes into Si-stereogenic silazanes has been developed. The chiral isothiourea catalyst (R)-benzotetramizole facilitates silylamination with sulfonamides, yielding (S)-silazanes with ≥99:1 er after one recrystallization. The approach is distinct from the conventional desymmetrization strategy using dihydrosilanes, expanding the synthetic toolbox for Si-stereogenic silazanes.