Journal of diabetes and its complications · 2026
Understanding the role of triglyceride glucose-body roundness index (TyG-BRI) in the paradigm of cognitive decline over time in patients with type 2 diabetes.
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Low Serena, Moh Angela, Zheng Huili, Goh Kiat Sern, Chuan Theedaraj Bun, Ang Keven, Tang Wern Ee, Lim Ziliang, Subramaniam Tavintharan, Sum Chee Fang, Lim Su Chi
Аннотация
AIMS: We investigated if triglyceride glucose-body roundness index (TyG-BRI) was longitudinally related to cognitive function in individuals who had type 2 diabetes (T2D), and possible mediation by arterial stiffness.
METHODS: In a prospective T2D cohort (N = 1412), we multiplied TyG (formula Ln [fasting triglyceride level - fasting plasma glucose / 2]) and BRI (formula 364.2-365.5 × √(1 - (waist circumference / 2ϖ)2 / (0.5 × height)2)) to derive TyG-BRI. We measured pulse wave velocity (PWV) using tonometry method. We determined cognitive performance with Repeatable Battery for Assessment for Neuropsychological Status(RBANS).
RESULTS: We observed an inverse relationship between Ln TyG-BRI and RBANS score (total) at baseline (coefficient -1.33, 95%CI -2.62, -0.40) in adjusted analysis. Among 823 patients with follow-up cognitive assessment up to 8.4 years, this inverse relationship persisted (coefficient -2.01, 95%CI -3.60, -0.41) in adjusted linear mixed model analysis. The patients with higher Ln TyG-BRI score experienced RBANS score reduction in delayed memory, visuo-spatial/construction and attention on follow-up. The relationship between Ln TyG-BRI and RBANS score(total) was mediated by PWV (proportion mediated = 16.8%).
CONCLUSIONS: TyG-BRI is a promising biomarker for reduction in cognitive function in overall and domains of memory, visuo-spatial/construction and attention in T2D. Our results provide mechanistic insights into mediating role of arterial stiffness in the relationship.
METHODS: In a prospective T2D cohort (N = 1412), we multiplied TyG (formula Ln [fasting triglyceride level - fasting plasma glucose / 2]) and BRI (formula 364.2-365.5 × √(1 - (waist circumference / 2ϖ)2 / (0.5 × height)2)) to derive TyG-BRI. We measured pulse wave velocity (PWV) using tonometry method. We determined cognitive performance with Repeatable Battery for Assessment for Neuropsychological Status(RBANS).
RESULTS: We observed an inverse relationship between Ln TyG-BRI and RBANS score (total) at baseline (coefficient -1.33, 95%CI -2.62, -0.40) in adjusted analysis. Among 823 patients with follow-up cognitive assessment up to 8.4 years, this inverse relationship persisted (coefficient -2.01, 95%CI -3.60, -0.41) in adjusted linear mixed model analysis. The patients with higher Ln TyG-BRI score experienced RBANS score reduction in delayed memory, visuo-spatial/construction and attention on follow-up. The relationship between Ln TyG-BRI and RBANS score(total) was mediated by PWV (proportion mediated = 16.8%).
CONCLUSIONS: TyG-BRI is a promising biomarker for reduction in cognitive function in overall and domains of memory, visuo-spatial/construction and attention in T2D. Our results provide mechanistic insights into mediating role of arterial stiffness in the relationship.