JACC. Case reports · 2025
Recurrent Heart Failure From Fulminant Giant Cell Myocarditis Following COVID-19 Infection Requiring Heart Transplantation.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Amedi Alan, Patel Jay N, Brennan Zachary, Dichiacchio Laura, Bowdish Michael, Gunn Tyler
Аннотация
BACKGROUND: Giant cell myocarditis (GCM) is a rare, rapidly progressive inflammatory cardiomyopathy marked by T cell-mediated myocardial destruction. Early diagnosis is difficult, and outcomes are poor without aggressive treatment.
CASE SUMMARY: A 46-year-old woman with recent COVID-19 presented with flulike symptoms and dyspnea. She rapidly decompensated into cardiogenic shock, requiring venoarterial extracorporeal membrane oxygenation. Endomyocardial biopsy revealed fulminant necrotizing myocarditis, prompting treatment with immunosuppressants. She was decannulated and discharged but returned 2 weeks later in shock, again requiring venoarterial extracorporeal membrane oxygenation. She ultimately underwent orthotopic heart transplantation. Explanted pathology confirmed GCM.
DISCUSSION: GCM can mimic other forms of myocarditis but requires biopsy for diagnosis. This case underscores the fulminant course of GCM, the utility of early mechanical support, and the importance of prompt recognition.
CASE SUMMARY: A 46-year-old woman with recent COVID-19 presented with flulike symptoms and dyspnea. She rapidly decompensated into cardiogenic shock, requiring venoarterial extracorporeal membrane oxygenation. Endomyocardial biopsy revealed fulminant necrotizing myocarditis, prompting treatment with immunosuppressants. She was decannulated and discharged but returned 2 weeks later in shock, again requiring venoarterial extracorporeal membrane oxygenation. She ultimately underwent orthotopic heart transplantation. Explanted pathology confirmed GCM.
DISCUSSION: GCM can mimic other forms of myocarditis but requires biopsy for diagnosis. This case underscores the fulminant course of GCM, the utility of early mechanical support, and the importance of prompt recognition.