microPublication biology · 2026
Exploring the Effects of Antioxidants on αSynuclein-Induced Motor Deficits in Drosophila Larvae.
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Perry Sarah, Zahraa Aljwmared, Beard Evan, Bonney Lorren, Brown Logan, Burkeen Jacob, Cardenas Wendy, Clark Faith, Conner Gary, Conrad Veronica, Freeman Melanie, Huycke Taylon, Jernigan Cruz Jay, Jones Presley, Jones Sherrita, Kubr Micah, Kyles Donnelle, McGuire KaMya, Moore Kathleen, Phillips Joel, Rains Trinity, Scharnhorst Bradly, Smith Betty, Stevens Hailey, Way Ryan
Аннотация
Parkinson's disease (PD) is marked by dopaminergic neuron loss, motor deficits, and oxidative stress. Misexpression of mutant human α-synuclein in Drosophila larvae induces PD-like motor impairments, making it a powerful and accessible model for studying neurodegeneration. In this Course-Based Undergraduate Research Experience (CURE), we used a novel Ring Maze assay to quantify larval locomotion following expression of A53T and E46K α-synuclein variants. Both induced robust crawling deficits. Notably, antioxidant treatment with vitamin C or açaí extract significantly improved motor performance. These findings demonstrate the value of the larval model for both PD research and hands-on student learning in neurobiology and therapeutic screening.